Skin Immune Landscape: Inside and Outside the Organism
The skin is an essential organ to the human body protecting it from external aggressions and pathogens. Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a high...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5095293 |
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| _version_ | 1832565524829044736 |
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| author | Florence Abdallah Lily Mijouin Chantal Pichon |
| author_facet | Florence Abdallah Lily Mijouin Chantal Pichon |
| author_sort | Florence Abdallah |
| collection | DOAJ |
| description | The skin is an essential organ to the human body protecting it from external aggressions and pathogens. Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a highly sophisticated compound known as the “skin immune system” (SIS). Studies of skin immune sentinels provided essential insights of a complex and dynamic immunity, which was achieved through interaction between the external and internal cutaneous compartments. In fact, the skin surface is cohabited by microorganisms recognized as skin microbiota that live in complete harmony with the immune sentinels and contribute to the epithelial barrier reinforcement. However, under stress, the symbiotic relationship changes into a dysbiotic one resulting in skin disorders. Hence, the skin microbiota may have either positive or negative influence on the immune system. This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense. |
| format | Article |
| id | doaj-art-b00889026b2e4921afc60fb7e73da6a3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b00889026b2e4921afc60fb7e73da6a32025-02-03T01:07:25ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/50952935095293Skin Immune Landscape: Inside and Outside the OrganismFlorence Abdallah0Lily Mijouin1Chantal Pichon2Centre de Biophysique Moléculaire, CNRS UPR4301, Orléans, FranceRemedials Laboratoire, 91 rue du Faubourg Saint-Honoré, 75008 Paris, FranceCentre de Biophysique Moléculaire, CNRS UPR4301, Orléans, FranceThe skin is an essential organ to the human body protecting it from external aggressions and pathogens. Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a highly sophisticated compound known as the “skin immune system” (SIS). Studies of skin immune sentinels provided essential insights of a complex and dynamic immunity, which was achieved through interaction between the external and internal cutaneous compartments. In fact, the skin surface is cohabited by microorganisms recognized as skin microbiota that live in complete harmony with the immune sentinels and contribute to the epithelial barrier reinforcement. However, under stress, the symbiotic relationship changes into a dysbiotic one resulting in skin disorders. Hence, the skin microbiota may have either positive or negative influence on the immune system. This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense.http://dx.doi.org/10.1155/2017/5095293 |
| spellingShingle | Florence Abdallah Lily Mijouin Chantal Pichon Skin Immune Landscape: Inside and Outside the Organism Mediators of Inflammation |
| title | Skin Immune Landscape: Inside and Outside the Organism |
| title_full | Skin Immune Landscape: Inside and Outside the Organism |
| title_fullStr | Skin Immune Landscape: Inside and Outside the Organism |
| title_full_unstemmed | Skin Immune Landscape: Inside and Outside the Organism |
| title_short | Skin Immune Landscape: Inside and Outside the Organism |
| title_sort | skin immune landscape inside and outside the organism |
| url | http://dx.doi.org/10.1155/2017/5095293 |
| work_keys_str_mv | AT florenceabdallah skinimmunelandscapeinsideandoutsidetheorganism AT lilymijouin skinimmunelandscapeinsideandoutsidetheorganism AT chantalpichon skinimmunelandscapeinsideandoutsidetheorganism |