Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives

Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives

Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead to atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRAs) with reduced side effects may act as a superior alternative to GCs. More than 30...

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Main Authors: Ekaterina M. Zhidkova, Evgeniya S. Oleynik, Ekaterina A. Mikhina, Daria V. Stepanycheva, Diana D. Grigoreva, Lyubov E. Grebenkina, Kirill V. Gordeev, Ekaterina D. Savina, Andrey V. Matveev, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
selective glucocorticoid receptor agonists
synephrine derivative synthesis
virtual docking
cytotoxicity
hematological malignancies
Online Access:https://www.mdpi.com/2218-273X/15/1/2
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