Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism
<i>Background</i>: The bite of the Loxosceles spider is a public health problem around the world, mainly in Latin America. The viscerocutaneous presentation is related to the inoculation of toxins (phospholipase-D) that generates a systemic inflammatory reaction with a subsequent increas...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/1/143 |
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| author | Raúl Valenzuela Córdova David Rivera Estrella José F. Bernardo Darío Jiménez Celia Rodríguez Tudero Raúl Elías José C. De La Flor |
| author_facet | Raúl Valenzuela Córdova David Rivera Estrella José F. Bernardo Darío Jiménez Celia Rodríguez Tudero Raúl Elías José C. De La Flor |
| author_sort | Raúl Valenzuela Córdova |
| collection | DOAJ |
| description | <i>Background</i>: The bite of the Loxosceles spider is a public health problem around the world, mainly in Latin America. The viscerocutaneous presentation is related to the inoculation of toxins (phospholipase-D) that generates a systemic inflammatory reaction with a subsequent increase in cytokines and chemokines. Hemoadsorption is proposed as a therapy that allows for the removal of the toxin and modulation of the inflammatory response in this disease. <i>Case Report</i>: We present the case of a 31-year-old woman who was admitted to the hospital due to decreased urinary flow and jaundice 48 h after a spider bite. Despite treatment with intravenous (IV) monovalent antiloxoscelism serum, antibiotic therapy, and corticosteroids, the patient’s evolution was poor, and she was admitted to the critical care unit for severe multi-organ involvement, including hepatic and kidney damage and coagulation disorders, eventually requiring hemodialysis support and hemoadsorption therapy. After the therapy was administered, rapid improvement was evident with the suspension of vasopressor support and a decrease in inflammatory markers. <i>Conclusions</i>: This case presents hemoadsorption as a therapeutic option, based on its capacity to reduce the intensity of hyperinflammation and to regulate the immunological response. |
| format | Article |
| id | doaj-art-afe2091490af4839b8bcf16e33e8d2e2 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-afe2091490af4839b8bcf16e33e8d2e22025-01-24T13:40:49ZengMDPI AGMedicina1010-660X1648-91442025-01-0161114310.3390/medicina61010143Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous LoxoscelismRaúl Valenzuela Córdova0David Rivera Estrella1José F. Bernardo2Darío Jiménez3Celia Rodríguez Tudero4Raúl Elías5José C. De La Flor6Department of Nephrology, Hospital Nacional Cayetano Heredia, Lima 15002, PeruDepartment of Nephrology, Hospital Nacional Cayetano Heredia, Lima 15002, PeruDepartment of Nephrology, Hospital Nacional Cayetano Heredia, Lima 15002, PeruCritical Nephrology Dialnef, Quito 170138, EcuadorDepartment of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, SpainDepartment of Nephrology, Hospital Nacional Cayetano Heredia, Lima 15002, PeruDepartment of Nephrology, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain<i>Background</i>: The bite of the Loxosceles spider is a public health problem around the world, mainly in Latin America. The viscerocutaneous presentation is related to the inoculation of toxins (phospholipase-D) that generates a systemic inflammatory reaction with a subsequent increase in cytokines and chemokines. Hemoadsorption is proposed as a therapy that allows for the removal of the toxin and modulation of the inflammatory response in this disease. <i>Case Report</i>: We present the case of a 31-year-old woman who was admitted to the hospital due to decreased urinary flow and jaundice 48 h after a spider bite. Despite treatment with intravenous (IV) monovalent antiloxoscelism serum, antibiotic therapy, and corticosteroids, the patient’s evolution was poor, and she was admitted to the critical care unit for severe multi-organ involvement, including hepatic and kidney damage and coagulation disorders, eventually requiring hemodialysis support and hemoadsorption therapy. After the therapy was administered, rapid improvement was evident with the suspension of vasopressor support and a decrease in inflammatory markers. <i>Conclusions</i>: This case presents hemoadsorption as a therapeutic option, based on its capacity to reduce the intensity of hyperinflammation and to regulate the immunological response.https://www.mdpi.com/1648-9144/61/1/143loxoscelismhemoadsorptionviscerocutaneous loxoscelism |
| spellingShingle | Raúl Valenzuela Córdova David Rivera Estrella José F. Bernardo Darío Jiménez Celia Rodríguez Tudero Raúl Elías José C. De La Flor Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism Medicina loxoscelism hemoadsorption viscerocutaneous loxoscelism |
| title | Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism |
| title_full | Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism |
| title_fullStr | Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism |
| title_full_unstemmed | Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism |
| title_short | Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism |
| title_sort | hemoadsorption in multiorgan failure due to viscerocutaneous loxoscelism |
| topic | loxoscelism hemoadsorption viscerocutaneous loxoscelism |
| url | https://www.mdpi.com/1648-9144/61/1/143 |
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