Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenol...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/547925 |
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| author | Romina P. Pizzolitto Carla L. Barberis José S. Dambolena Jimena M. Herrera María P. Zunino Carina E. Magnoli Héctor R. Rubinstein Julio A. Zygadlo Ana M. Dalcero |
| author_facet | Romina P. Pizzolitto Carla L. Barberis José S. Dambolena Jimena M. Herrera María P. Zunino Carina E. Magnoli Héctor R. Rubinstein Julio A. Zygadlo Ana M. Dalcero |
| author_sort | Romina P. Pizzolitto |
| collection | DOAJ |
| description | Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM, and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity. |
| format | Article |
| id | doaj-art-afe0e2d2a09c4133a20f01302f6cd543 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-afe0e2d2a09c4133a20f01302f6cd5432025-02-03T05:43:44ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/547925547925Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus GrowthRomina P. Pizzolitto0Carla L. Barberis1José S. Dambolena2Jimena M. Herrera3María P. Zunino4Carina E. Magnoli5Héctor R. Rubinstein6Julio A. Zygadlo7Ana M. Dalcero8Instituto Multidisciplinario de Biología Vegetal (IMBiV-CONICET), Universidad Nacional de Córdoba, ICTA, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba, ArgentinaDepartamento de Microbiología e Inmunología, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta 36 Km 601, X5804BY Río Cuarto, Córdoba, ArgentinaInstituto Multidisciplinario de Biología Vegetal (IMBiV-CONICET), Universidad Nacional de Córdoba, ICTA, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba, ArgentinaInstituto Multidisciplinario de Biología Vegetal (IMBiV-CONICET), Universidad Nacional de Córdoba, ICTA, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba, ArgentinaInstituto Multidisciplinario de Biología Vegetal (IMBiV-CONICET), Universidad Nacional de Córdoba, ICTA, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba, ArgentinaDepartamento de Microbiología e Inmunología, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta 36 Km 601, X5804BY Río Cuarto, Córdoba, ArgentinaCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5016GCA Córdoba, ArgentinaInstituto Multidisciplinario de Biología Vegetal (IMBiV-CONICET), Universidad Nacional de Córdoba, ICTA, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba, ArgentinaDepartamento de Microbiología e Inmunología, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta 36 Km 601, X5804BY Río Cuarto, Córdoba, ArgentinaConsidering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM, and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity.http://dx.doi.org/10.1155/2015/547925 |
| spellingShingle | Romina P. Pizzolitto Carla L. Barberis José S. Dambolena Jimena M. Herrera María P. Zunino Carina E. Magnoli Héctor R. Rubinstein Julio A. Zygadlo Ana M. Dalcero Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth Journal of Chemistry |
| title | Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth |
| title_full | Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth |
| title_fullStr | Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth |
| title_full_unstemmed | Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth |
| title_short | Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth |
| title_sort | inhibitory effect of natural phenolic compounds on aspergillus parasiticus growth |
| url | http://dx.doi.org/10.1155/2015/547925 |
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