Whole RNA-Seq Analysis Reveals Longitudinal Proteostasis Network Responses to Photoreceptor Outer Segment Trafficking and Degradation in RPE Cells

Whole RNA-Seq Analysis Reveals Longitudinal Proteostasis Network Responses to Photoreceptor Outer Segment Trafficking and Degradation in RPE Cells

RNA-seq analysis of the highly differentiated human retinal pigment epithelial (RPE) cell-line ARPE-19, cultured on transwells for ≥4 months, yielded 44,909 genes showing 83.35% alignment with the human reference genome. These included mRNA transcripts of RPE-specific genes and those involved in ret...

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Bibliographic Details
Main Authors: Rebecca D. Miller, Isaac Mondon, Charles Ellis, Anna-Marie Muir, Stephanie Turner, Eloise Keeling, Htoo A. Wai, David S. Chatelet, David A. Johnson, David A. Tumbarello, Andrew J. Lotery, Diana Baralle, J. Arjuna Ratnayaka
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
retinal pigment epithelium (RPE)
RNA-seq
photoreceptor outer segments (POS)
trafficking
proteostasis
age-related macular degeneration (AMD)
Online Access:https://www.mdpi.com/2073-4409/14/15/1166
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