Effect of Phenylephrine on the Accommodative System
Accommodation is controlled by the action of the ciliary muscle and mediated primarily by parasympathetic input through postganglionic fibers that originate from neurons in the ciliary and pterygopalatine ganglia. During accommodation the pupil constricts to increase the depth of focus of the eye an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/7968918 |
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| author | José J. Esteve-Taboada Antonio J. Del Águila-Carrasco Paula Bernal-Molina Teresa Ferrer-Blasco Norberto López-Gil Robert Montés-Micó |
| author_facet | José J. Esteve-Taboada Antonio J. Del Águila-Carrasco Paula Bernal-Molina Teresa Ferrer-Blasco Norberto López-Gil Robert Montés-Micó |
| author_sort | José J. Esteve-Taboada |
| collection | DOAJ |
| description | Accommodation is controlled by the action of the ciliary muscle and mediated primarily by parasympathetic input through postganglionic fibers that originate from neurons in the ciliary and pterygopalatine ganglia. During accommodation the pupil constricts to increase the depth of focus of the eye and improve retinal image quality. Researchers have traditionally faced the challenge of measuring the accommodative properties of the eye through a small pupil and thus have relied on pharmacological agents to dilate the pupil. Achieving pupil dilation (mydriasis) without affecting the accommodative ability of the eye (cycloplegia) could be useful in many clinical and research contexts. Phenylephrine hydrochloride (PHCl) is a sympathomimetic agent that is used clinically to dilate the pupil. Nevertheless, first investigations suggested some loss of functional accommodation in the human eye after PHCl instillation. Subsequent studies, based on different measurement procedures, obtained contradictory conclusions, causing therefore an unexpected controversy that has been spread almost to the present days. This manuscript reviews and summarizes the main research studies that have been performed to analyze the effect of PHCl on the accommodative system and provides clear conclusions that could help clinicians know the real effects of PHCl on the accommodative system of the human eye. |
| format | Article |
| id | doaj-art-afdc94c1bbbb4fc49187aed573088a02 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-afdc94c1bbbb4fc49187aed573088a022025-02-03T05:58:44ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/79689187968918Effect of Phenylephrine on the Accommodative SystemJosé J. Esteve-Taboada0Antonio J. Del Águila-Carrasco1Paula Bernal-Molina2Teresa Ferrer-Blasco3Norberto López-Gil4Robert Montés-Micó5Department of Optics and Optometry and Visual Sciences, University of Valencia, Valencia, SpainDepartment of Optics and Optometry and Visual Sciences, University of Valencia, Valencia, SpainDepartment of Optics and Optometry and Visual Sciences, University of Valencia, Valencia, SpainDepartment of Optics and Optometry and Visual Sciences, University of Valencia, Valencia, SpainMixed group UVEG-UMU, Interuniversity Laboratory for Research in Vision and Optometry, Valencia, SpainDepartment of Optics and Optometry and Visual Sciences, University of Valencia, Valencia, SpainAccommodation is controlled by the action of the ciliary muscle and mediated primarily by parasympathetic input through postganglionic fibers that originate from neurons in the ciliary and pterygopalatine ganglia. During accommodation the pupil constricts to increase the depth of focus of the eye and improve retinal image quality. Researchers have traditionally faced the challenge of measuring the accommodative properties of the eye through a small pupil and thus have relied on pharmacological agents to dilate the pupil. Achieving pupil dilation (mydriasis) without affecting the accommodative ability of the eye (cycloplegia) could be useful in many clinical and research contexts. Phenylephrine hydrochloride (PHCl) is a sympathomimetic agent that is used clinically to dilate the pupil. Nevertheless, first investigations suggested some loss of functional accommodation in the human eye after PHCl instillation. Subsequent studies, based on different measurement procedures, obtained contradictory conclusions, causing therefore an unexpected controversy that has been spread almost to the present days. This manuscript reviews and summarizes the main research studies that have been performed to analyze the effect of PHCl on the accommodative system and provides clear conclusions that could help clinicians know the real effects of PHCl on the accommodative system of the human eye.http://dx.doi.org/10.1155/2016/7968918 |
| spellingShingle | José J. Esteve-Taboada Antonio J. Del Águila-Carrasco Paula Bernal-Molina Teresa Ferrer-Blasco Norberto López-Gil Robert Montés-Micó Effect of Phenylephrine on the Accommodative System Journal of Ophthalmology |
| title | Effect of Phenylephrine on the Accommodative System |
| title_full | Effect of Phenylephrine on the Accommodative System |
| title_fullStr | Effect of Phenylephrine on the Accommodative System |
| title_full_unstemmed | Effect of Phenylephrine on the Accommodative System |
| title_short | Effect of Phenylephrine on the Accommodative System |
| title_sort | effect of phenylephrine on the accommodative system |
| url | http://dx.doi.org/10.1155/2016/7968918 |
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