Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals
Equine piroplasmosis is a tick-borne disease mainly caused by Theileria equi and Babesia caballi. The objectives of this study were to analyse the frequency and routes of vertical transmission of these blood parasites from 179 asymptomatic mares to their foals. Foals were sampled within 72 h post-pa...
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Elsevier
2025-01-01
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| Series: | Ticks and Tick-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1877959X24001250 |
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| author | Lisa-Marie Hermans Claire Bonsergent Anne Josson Gloria Rocafort-Ferrer Marine Le Guyader Sophie Angelloz-Pessey Agnès Leblond Laurence Malandrin |
| author_facet | Lisa-Marie Hermans Claire Bonsergent Anne Josson Gloria Rocafort-Ferrer Marine Le Guyader Sophie Angelloz-Pessey Agnès Leblond Laurence Malandrin |
| author_sort | Lisa-Marie Hermans |
| collection | DOAJ |
| description | Equine piroplasmosis is a tick-borne disease mainly caused by Theileria equi and Babesia caballi. The objectives of this study were to analyse the frequency and routes of vertical transmission of these blood parasites from 179 asymptomatic mares to their foals. Foals were sampled within 72 h post-partum. The seroprevalences determined by Indirect Immunofluorescent Antibody Test (IFAT) and based on a subset sample of 107 couples, were 59.8% and 42.1% for T. equi and B. caballi, respectively in the mare population, and 54.2% and 40.2% in the foal population. A species-specific nested PCR was performed on all blood samples (358) and on available samples of placenta (24), umbilicus (6) and colostrum (18). For mares, 30.2% (54/179) and 2.2% (4/179) were PCR-positive for T. equi and B. caballi, respectively. Vertical transmission was not observed in the case of B. caballi, and four foals were born T. equi PCR-positive, giving a transmission rate of 7.4% (4/54). The blood smear evaluation showed viable T. equi parasites for the four foals without clinical signs of neonatal equine piroplasmosis, but one foal had acute renal failure. Theileria equi DNA was detected in umbilical cords, placenta and/or colostrum from PCR-positive mares, without correlation with the carrier status of the foal. One foal was born carrier but T. equi DNA had not been detected in the placenta. The 18S rRNA genotype E of T. equi was characterized in the four foals, foetal parts of the placenta and colostrum. The routes of transmission and particularly the possibility of colostral passage warrant further investigation. |
| format | Article |
| id | doaj-art-afd9d2395b114bf3b7e188ae51cf6243 |
| institution | Kabale University |
| issn | 1877-9603 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ticks and Tick-Borne Diseases |
| spelling | doaj-art-afd9d2395b114bf3b7e188ae51cf62432025-02-05T04:31:31ZengElsevierTicks and Tick-Borne Diseases1877-96032025-01-01161102432Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foalsLisa-Marie Hermans0Claire Bonsergent1Anne Josson2Gloria Rocafort-Ferrer3Marine Le Guyader4Sophie Angelloz-Pessey5Agnès Leblond6Laurence Malandrin7Clinical Department of Companion, Leisure and Sports Animals, VetAgro Sup, University of Lyon, Marcy l'Etoile 69280, France; UMR EPIA, INRAE, VetAgro Sup, University of Lyon, Marcy l'Etoile, 69280, France; Corresponding author at: Tierklinik Telgte (equine hospital Telgte), Telgte 48291, Germany.INRAE, Oniris, BIOEPAR, Nantes 44300, FranceClinical Department of Companion, Leisure and Sports Animals, VetAgro Sup, University of Lyon, Marcy l'Etoile 69280, FranceLa Clinique du Cheval, Centre Hospitalier Vétérinaire Équin, Grenade 31330, FrancePôle d'Analyse de VetAgro Sup, VetAgro Sup Marcy l'Etoile, 69280 FrancePôle d'Analyse de VetAgro Sup, VetAgro Sup Marcy l'Etoile, 69280 FranceClinical Department of Companion, Leisure and Sports Animals, VetAgro Sup, University of Lyon, Marcy l'Etoile 69280, France; UMR EPIA, INRAE, VetAgro Sup, University of Lyon, Marcy l'Etoile, 69280, FranceINRAE, Oniris, BIOEPAR, Nantes 44300, FranceEquine piroplasmosis is a tick-borne disease mainly caused by Theileria equi and Babesia caballi. The objectives of this study were to analyse the frequency and routes of vertical transmission of these blood parasites from 179 asymptomatic mares to their foals. Foals were sampled within 72 h post-partum. The seroprevalences determined by Indirect Immunofluorescent Antibody Test (IFAT) and based on a subset sample of 107 couples, were 59.8% and 42.1% for T. equi and B. caballi, respectively in the mare population, and 54.2% and 40.2% in the foal population. A species-specific nested PCR was performed on all blood samples (358) and on available samples of placenta (24), umbilicus (6) and colostrum (18). For mares, 30.2% (54/179) and 2.2% (4/179) were PCR-positive for T. equi and B. caballi, respectively. Vertical transmission was not observed in the case of B. caballi, and four foals were born T. equi PCR-positive, giving a transmission rate of 7.4% (4/54). The blood smear evaluation showed viable T. equi parasites for the four foals without clinical signs of neonatal equine piroplasmosis, but one foal had acute renal failure. Theileria equi DNA was detected in umbilical cords, placenta and/or colostrum from PCR-positive mares, without correlation with the carrier status of the foal. One foal was born carrier but T. equi DNA had not been detected in the placenta. The 18S rRNA genotype E of T. equi was characterized in the four foals, foetal parts of the placenta and colostrum. The routes of transmission and particularly the possibility of colostral passage warrant further investigation.http://www.sciencedirect.com/science/article/pii/S1877959X24001250Equine piroplasmosisTheileria equiVertical transmissionColostrumPlacenta |
| spellingShingle | Lisa-Marie Hermans Claire Bonsergent Anne Josson Gloria Rocafort-Ferrer Marine Le Guyader Sophie Angelloz-Pessey Agnès Leblond Laurence Malandrin Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals Ticks and Tick-Borne Diseases Equine piroplasmosis Theileria equi Vertical transmission Colostrum Placenta |
| title | Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| title_full | Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| title_fullStr | Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| title_full_unstemmed | Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| title_short | Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| title_sort | evaluation of theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals |
| topic | Equine piroplasmosis Theileria equi Vertical transmission Colostrum Placenta |
| url | http://www.sciencedirect.com/science/article/pii/S1877959X24001250 |
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