Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles
Background. Extrasystoles may be useful for predicting the response to fluid therapy in hemodynamically unstable patients but their prevalence is unknown. The aim of this study was to estimate the availability of extrasystoles in intensive care unit patients diagnosed with sepsis. The study aim was...
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Wiley
2018-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5697092 |
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| author | Johannes Enevoldsen Cristhian Potes Minnan Xu-Wilson Simon T. Vistisen |
| author_facet | Johannes Enevoldsen Cristhian Potes Minnan Xu-Wilson Simon T. Vistisen |
| author_sort | Johannes Enevoldsen |
| collection | DOAJ |
| description | Background. Extrasystoles may be useful for predicting the response to fluid therapy in hemodynamically unstable patients but their prevalence is unknown. The aim of this study was to estimate the availability of extrasystoles in intensive care unit patients diagnosed with sepsis. The study aim was not to validate the fluid responsiveness prediction ability of extrasystoles. Methods. Twenty-four-hour ECG recordings from a convenience sample of 50 patients diagnosed with sepsis were extracted from the MIMIC-II waveform database, and ECGs were visually examined for correct QRS complex detection. Custom-made algorithms identified potential extrasystoles based on RR intervals. Two raters visually confirmed or rejected the potential extrasystoles and then classified them as ventricular, supraventricular, or unknown origin. Extrasystole availability was calculated as extrasystolic coverage for each 24 h ECG recording, that is, the percentage of the 24 h recording where an extrasystole had occurred in the preceding 30 minutes. Results. Mean extrasystolic coverage was 53.3% (confidence interval: [42.8; 63.6]%) and ventricular extrasystolic coverage was 21.4 [13.5; 29.8]%. Interrater reliability was strong for confirming/rejecting extrasystoles. Conclusions. Extrasystoles are available for fluid responsiveness prediction in septic patients in about half of the time. With this extrasystolic availability, we believe the method to be considered for clinical use, provided that future studies validate the method’s fluid responsiveness prediction ability. |
| format | Article |
| id | doaj-art-afbe8de7b0944be59f55427e1e65b3f7 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-afbe8de7b0944be59f55427e1e65b3f72025-02-03T01:26:20ZengWileyCritical Care Research and Practice2090-13052090-13132018-01-01201810.1155/2018/56970925697092Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using ExtrasystolesJohannes Enevoldsen0Cristhian Potes1Minnan Xu-Wilson2Simon T. Vistisen3Research Centre for Emergency Medicine, Institute of Clinical Medicine, Aarhus University, Aarhus, DenmarkAcute Care Solutions Department, Philips Research North America, Boston, MA, USAAcute Care Solutions Department, Philips Research North America, Boston, MA, USAResearch Centre for Emergency Medicine, Institute of Clinical Medicine, Aarhus University, Aarhus, DenmarkBackground. Extrasystoles may be useful for predicting the response to fluid therapy in hemodynamically unstable patients but their prevalence is unknown. The aim of this study was to estimate the availability of extrasystoles in intensive care unit patients diagnosed with sepsis. The study aim was not to validate the fluid responsiveness prediction ability of extrasystoles. Methods. Twenty-four-hour ECG recordings from a convenience sample of 50 patients diagnosed with sepsis were extracted from the MIMIC-II waveform database, and ECGs were visually examined for correct QRS complex detection. Custom-made algorithms identified potential extrasystoles based on RR intervals. Two raters visually confirmed or rejected the potential extrasystoles and then classified them as ventricular, supraventricular, or unknown origin. Extrasystole availability was calculated as extrasystolic coverage for each 24 h ECG recording, that is, the percentage of the 24 h recording where an extrasystole had occurred in the preceding 30 minutes. Results. Mean extrasystolic coverage was 53.3% (confidence interval: [42.8; 63.6]%) and ventricular extrasystolic coverage was 21.4 [13.5; 29.8]%. Interrater reliability was strong for confirming/rejecting extrasystoles. Conclusions. Extrasystoles are available for fluid responsiveness prediction in septic patients in about half of the time. With this extrasystolic availability, we believe the method to be considered for clinical use, provided that future studies validate the method’s fluid responsiveness prediction ability.http://dx.doi.org/10.1155/2018/5697092 |
| spellingShingle | Johannes Enevoldsen Cristhian Potes Minnan Xu-Wilson Simon T. Vistisen Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles Critical Care Research and Practice |
| title | Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles |
| title_full | Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles |
| title_fullStr | Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles |
| title_full_unstemmed | Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles |
| title_short | Prevalence and Temporal Distribution of Extrasystoles in Septic ICU Patients: The Feasibility of Predicting Fluid Responsiveness Using Extrasystoles |
| title_sort | prevalence and temporal distribution of extrasystoles in septic icu patients the feasibility of predicting fluid responsiveness using extrasystoles |
| url | http://dx.doi.org/10.1155/2018/5697092 |
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