Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study
This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency of Entamoeba histolytica cysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in...
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| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.174 |
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| author | Nicolas Padilla Rosalinda Diaz Alfonso Alarcon Roberto Barreda |
| author_facet | Nicolas Padilla Rosalinda Diaz Alfonso Alarcon Roberto Barreda |
| author_sort | Nicolas Padilla |
| collection | DOAJ |
| description | This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency of Entamoeba histolytica cysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence of E. histolytica cysts after a parasitoscopic analysis by concentration (PSC) in three samples over consecutive days using Faust’s method. Those included in the study received a single 4.3-g/kg dose of quinfamide, and we performed PSC on days 5, 6, and 7 following dose administration to examine whether quinfamide had affected the presence of the cysts. The study participants who tested negative for cysts were divided into three groups: Group 1 had 102 patients who underwent quinfamide treatment and three CPS analyses after the 12 months of the study; Group 2 had 98 subjects who underwent the quinfamide treatment and three CPS analyses at months 3, 6, 9, and 12 after their entrance into the study; and Group 3 had 102 patients, who underwent the quinfamide treatment and series of three CPS analyses at months 6 and 12 of the study. All participants received the dose of quinfamide after providing stool samples and after a clinical gastrointestinal history was obtained. Further clinical gastrointestinal data were collected 5 days after the quintamide dose was administered. We used EpiInfo 6.0 for statistical analysis, calculating X2 and p values for the clinical data and the CPS data after the 12 months concluded. Of the initial samples of 1,524 subjects, 308 (20.2%) had Entamoebic cysts. Of these, six were further eliminated because they did not meet the inclusion requirements. At the conclusion of the study, Group 1 presented with 37.6% of subjects still testing positive for cysts; of Group 2, 12.5% tested positive; and in Group 3, 23.5% of participants tested positive for cysts (X2 = 16.8; df = 2; p = 0.0002). For comparisons of groups 1 and 2 and 1 and 3, p > 0.05. We conclude that antiamoebic chemoprophylaxis can be a choice for control of amoebic infection where personal hygiene and food consumption habits are not improving. |
| format | Article |
| id | doaj-art-afb9a60228c14771865fa8f0097eba2c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-afb9a60228c14771865fa8f0097eba2c2025-02-03T01:31:42ZengWileyThe Scientific World Journal1537-744X2002-01-0121070107810.1100/tsw.2002.174Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative StudyNicolas Padilla0Rosalinda Diaz1Alfonso Alarcon2Roberto Barreda3Unidad de Investigacion, Escuela de Enfermeria y Obstetricia de Celaya, Universidad de Guanajuato, Searle de Mexico, S.A. de C.V., MexicoUnidad de Investigacion, Escuela de Enfermeria y Obstetricia de Celaya, Universidad de Guanajuato, Searle de Mexico, S.A. de C.V., MexicoDirección Médica, Searle de Mexico, S.A. de C.V., MexicoDirección Médica, Searle de Mexico, S.A. de C.V., MexicoThis study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency of Entamoeba histolytica cysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence of E. histolytica cysts after a parasitoscopic analysis by concentration (PSC) in three samples over consecutive days using Faust’s method. Those included in the study received a single 4.3-g/kg dose of quinfamide, and we performed PSC on days 5, 6, and 7 following dose administration to examine whether quinfamide had affected the presence of the cysts. The study participants who tested negative for cysts were divided into three groups: Group 1 had 102 patients who underwent quinfamide treatment and three CPS analyses after the 12 months of the study; Group 2 had 98 subjects who underwent the quinfamide treatment and three CPS analyses at months 3, 6, 9, and 12 after their entrance into the study; and Group 3 had 102 patients, who underwent the quinfamide treatment and series of three CPS analyses at months 6 and 12 of the study. All participants received the dose of quinfamide after providing stool samples and after a clinical gastrointestinal history was obtained. Further clinical gastrointestinal data were collected 5 days after the quintamide dose was administered. We used EpiInfo 6.0 for statistical analysis, calculating X2 and p values for the clinical data and the CPS data after the 12 months concluded. Of the initial samples of 1,524 subjects, 308 (20.2%) had Entamoebic cysts. Of these, six were further eliminated because they did not meet the inclusion requirements. At the conclusion of the study, Group 1 presented with 37.6% of subjects still testing positive for cysts; of Group 2, 12.5% tested positive; and in Group 3, 23.5% of participants tested positive for cysts (X2 = 16.8; df = 2; p = 0.0002). For comparisons of groups 1 and 2 and 1 and 3, p > 0.05. We conclude that antiamoebic chemoprophylaxis can be a choice for control of amoebic infection where personal hygiene and food consumption habits are not improving.http://dx.doi.org/10.1100/tsw.2002.174 |
| spellingShingle | Nicolas Padilla Rosalinda Diaz Alfonso Alarcon Roberto Barreda Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study The Scientific World Journal |
| title | Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study |
| title_full | Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study |
| title_fullStr | Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study |
| title_full_unstemmed | Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study |
| title_short | Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study |
| title_sort | antiamoebic chemoprophylaxis using quinfamide in children a comparative study |
| url | http://dx.doi.org/10.1100/tsw.2002.174 |
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