Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke

Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke

Abstract Background Stroke is a leading cause of death and disability worldwide, yet its treatment still faces significant challenges. Mendelian randomization (MR) has been widely used to discover new biomarkers and therapeutic targets. This study aimed to identify therapeutic targets for stroke wit...

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Bibliographic Details
Main Authors: Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neurology
Subjects:
Stroke
Ischemic stroke
Plasma proteins
Mendelian randomization
Drug targets
Online Access:https://doi.org/10.1186/s12883-025-04239-9
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