TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Abstract The global incidence of Metabolic dysfunction‐associated steatohepatitis (MASH) is increasing, highlighting the urgent need for new treatment strategies. This study aimed to investigate the involvement of tripartite motif‐containing 25 (TRIM25) in MASH progression and explore the therapeuti...

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Bibliographic Details
Main Authors: Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
C27H26N2O4S
exosomes
lipid metabolism
MASH
targeted delivery
TRIM25
Online Access:https://doi.org/10.1002/advs.202414646
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https://doi.org/10.1002/advs.202414646

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