Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry

Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry

BackgroundOsteoarthritis (OA) is a chronic joint condition that causes pain, limited mobility, and reduced quality of life, posing a threat to healthy aging. Early detection is crucial for improving prognosis. Recent research has focused on the role of ubiquitination-related genes (URGs) in early OA...

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Bibliographic Details
Main Authors: Yiwei Chen, Jiali Lin, Detong Shi, Yu Miao, Feng Xue, Kexin Liu, Xiaotao Wang, Changqing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
ubiquitination
machine learning
single-cell RNA sequencing
diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517646/full
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