Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study
Inflammation plays a pivotal role in all stages of atherosclerosis. Numerous inflammatory, lipid, and cytokines markers have been associated with coronary artery disease (CAD) risk but data directly comparing their predictive value are limited. Studies were carried to elucidate the role of high-sens...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/389235 |
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| author | Veena S. Rao Natesha B. Kadarinarasimhiah Shibu John Sridhara Hebbagodi Jayashree Shanker Vijay V. Kakkar |
| author_facet | Veena S. Rao Natesha B. Kadarinarasimhiah Shibu John Sridhara Hebbagodi Jayashree Shanker Vijay V. Kakkar |
| author_sort | Veena S. Rao |
| collection | DOAJ |
| description | Inflammation plays a pivotal role in all stages of atherosclerosis. Numerous inflammatory, lipid, and cytokines markers have been associated with coronary artery disease (CAD) risk but data directly comparing their predictive value are limited. Studies were carried to elucidate the role of high-sensitivity C-reactive protein (hsCRP), other inflammatory as well as lipid markers and their associations. Among 1021 subjects, comprising 774 CAD affected members from Indian Atherosclerosis Research Study (IARS), plasma hsCRP levels showed strong correlation with inflammatory markers, namely, IL6 (r=.373; P=<.0001), sPLA2 (r=.544; P=<.0001) as also with fibrinogen (r=.579; P=<.0001). Levels of hsCRP were higher among subjects affected by CAD who suffered a repeat coronary event as compared to those who remained event free and subjects in the top quartile of hsCRP (>3.58 mg/L) were found to have a fourfold higher risk. In conclusion, hsCRP appears to be an independent predictor of recurrent CAD events in Asian Indian population. |
| format | Article |
| id | doaj-art-af73099306d64c1ba13fc700e6924455 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-af73099306d64c1ba13fc700e69244552025-02-03T06:43:47ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/389235389235Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research StudyVeena S. Rao0Natesha B. Kadarinarasimhiah1Shibu John2Sridhara Hebbagodi3Jayashree Shanker4Vijay V. Kakkar5Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, India, Narayana Hrudayalaya Hospital, 560099 Bangalore, IndiaTata Proteomics and Coagulation Unit, Thrombosis Research Institute, India, Narayana Hrudayalaya Hospital, 560099 Bangalore, IndiaElizabeth and Emmanuel Kaye Bioinformatics and Statistical Unit, Thrombosis Research Institute, 560099 Bangalore, IndiaElizabeth and Emmanuel Kaye Bioinformatics and Statistical Unit, Thrombosis Research Institute, 560099 Bangalore, IndiaGarry and Mary Weston Functional Genomics Unit, Thrombosis Research Institute, 560099 Bangalore, IndiaThrombosis Research Institute, Manresa Road, Chelsea, SW36LR London, UKInflammation plays a pivotal role in all stages of atherosclerosis. Numerous inflammatory, lipid, and cytokines markers have been associated with coronary artery disease (CAD) risk but data directly comparing their predictive value are limited. Studies were carried to elucidate the role of high-sensitivity C-reactive protein (hsCRP), other inflammatory as well as lipid markers and their associations. Among 1021 subjects, comprising 774 CAD affected members from Indian Atherosclerosis Research Study (IARS), plasma hsCRP levels showed strong correlation with inflammatory markers, namely, IL6 (r=.373; P=<.0001), sPLA2 (r=.544; P=<.0001) as also with fibrinogen (r=.579; P=<.0001). Levels of hsCRP were higher among subjects affected by CAD who suffered a repeat coronary event as compared to those who remained event free and subjects in the top quartile of hsCRP (>3.58 mg/L) were found to have a fourfold higher risk. In conclusion, hsCRP appears to be an independent predictor of recurrent CAD events in Asian Indian population.http://dx.doi.org/10.1155/2010/389235 |
| spellingShingle | Veena S. Rao Natesha B. Kadarinarasimhiah Shibu John Sridhara Hebbagodi Jayashree Shanker Vijay V. Kakkar Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study International Journal of Vascular Medicine |
| title | Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study |
| title_full | Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study |
| title_fullStr | Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study |
| title_full_unstemmed | Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study |
| title_short | Usefulness of C-Reactive Protein as a Marker for Prediction of Future Coronary Events in the Asian Indian Population: Indian Atherosclerosis Research Study |
| title_sort | usefulness of c reactive protein as a marker for prediction of future coronary events in the asian indian population indian atherosclerosis research study |
| url | http://dx.doi.org/10.1155/2010/389235 |
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