SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathema...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2014-12-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/50 |
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| author | E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko |
| author_facet | E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko |
| author_sort | E. L. Mishchenko |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathematical model for subgenomic HCVreplicon replication in Huh-7 cells with the presence ofthe HCVNS3 protease inhibitor SCH 503034 is proposed. The model describes the experimental kinetic curves ofviral RNAsuppression at various SCH 503034 concentrations. It is applicable to the development ofapproaches to HCVRNAsuppression in Huh-7 cells. |
| format | Article |
| id | doaj-art-af6ec3b20bcc40a291d8efa485a1dd5c |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-af6ec3b20bcc40a291d8efa485a1dd5c2025-02-01T09:57:58ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592014-12-0116233934734SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODELE. L. Mishchenko0N. V. Ivanisenko1I. R. Akberdin2P. S. Demenkov3V. A. Likhoshvai4N. A. Kolchanov5V. A. Ivanisenko6Institute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaHepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathematical model for subgenomic HCVreplicon replication in Huh-7 cells with the presence ofthe HCVNS3 protease inhibitor SCH 503034 is proposed. The model describes the experimental kinetic curves ofviral RNAsuppression at various SCH 503034 concentrations. It is applicable to the development ofapproaches to HCVRNAsuppression in Huh-7 cells.https://vavilov.elpub.ru/jour/article/view/50hepatitis c virussubgenomic repliconmathematical modelingeffectiveness of drugs |
| spellingShingle | E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL Вавиловский журнал генетики и селекции hepatitis c virus subgenomic replicon mathematical modeling effectiveness of drugs |
| title | SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL |
| title_full | SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL |
| title_fullStr | SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL |
| title_full_unstemmed | SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL |
| title_short | SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL |
| title_sort | suppression of subgenomic hepatitis c virus rna replicon replication in huh 7 cells by the ns3 protease inhibitor sch5030334 a stochastic mathematical model |
| topic | hepatitis c virus subgenomic replicon mathematical modeling effectiveness of drugs |
| url | https://vavilov.elpub.ru/jour/article/view/50 |
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