GOOD OUTCOME FOR VERY HIGH RISK ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA CARRYING GENETIC ABNORMALITIES t(4;11)(q21;q23) or t(9;22)(q34;q11), IF PROMPTLY SUBMITTED TO ALLOGENEIC TRANSPLANTATION, AFTER OBTAINING A GOOD MOLECULAR REMISSION.

GOOD OUTCOME FOR VERY HIGH RISK ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA CARRYING GENETIC ABNORMALITIES t(4;11)(q21;q23) or t(9;22)(q34;q11), IF PROMPTLY SUBMITTED TO ALLOGENEIC TRANSPLANTATION, AFTER OBTAINING A GOOD MOLECULAR REMISSION.

Background and Objectives: Acute lymphoblastic leukaemia (ALL) carrying t(9;22) or t(4;11) genetic abnormalities represents a very high risk subtype of disease (VHR-ALL). Hematopoietic stem cell transplantation (HSCT) still remains the only curative option also in the Imatinib era. In the last years...

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Main Authors: Matteo Parma, Clara Vigano', Monica Fumagalli, Federica Colnaghi, Arianna Colombo, Federica Mottadelli, Vincenzo Rossi, Elena Elli, Elisabetta Terruzzi, Angelo Belotti, Giovanni Cazzaniga, Enrico Maria Pogliani, Pietro Pioltelli
Format: Article
Language:English
Published: PAGEPress Publications 2015-05-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
Acute Lymphoblastic Leukemia
Bone marrow transplantation
Minimal Residual Disease
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/2307
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