Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis
Sarcoidosis is a multisystem disease with unknown etiology, marked by T lymphocytes and macrophages agglomeration, which leads to the formation of noncaseating granulomas in the affected tissues. We describe a case of a 40-year-old black patient referred to our service for evaluation of nephrolithia...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2019/6483245 |
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| author | Matheus Campello Vieira Priscilla Gomes Tosta Fernanda Morello Nicole Lucas Enock V. Roberto Júlia Guasti P. Vianna Paulo de Coelho Castro Rafael Burgomeister Lourenço Erica Vieira Serrano Valéria Valim Weverton Machado Luchi |
| author_facet | Matheus Campello Vieira Priscilla Gomes Tosta Fernanda Morello Nicole Lucas Enock V. Roberto Júlia Guasti P. Vianna Paulo de Coelho Castro Rafael Burgomeister Lourenço Erica Vieira Serrano Valéria Valim Weverton Machado Luchi |
| author_sort | Matheus Campello Vieira |
| collection | DOAJ |
| description | Sarcoidosis is a multisystem disease with unknown etiology, marked by T lymphocytes and macrophages agglomeration, which leads to the formation of noncaseating granulomas in the affected tissues. We describe a case of a 40-year-old black patient referred to our service for evaluation of nephrolithiasis and persistent elevation of plasma creatinine. He reported important weight loss, fever episodes, and abdominal and low back intermittent pain in the past 6 months. The investigation revealed elevated serum calcium level, hepatosplenomegaly, retroperitoneal lymphadenopathy, anemia, thrombocytopenia, and nephrolithiasis. The initial diagnostic hypothesis was lymphoproliferative disease, but the laparoscopic propaedeutic showed multiple white lesions on the liver surface, which biopsy identified as noncaseating granulomas with asteroid corpuscles, suggestive of sarcoidosis. He was treated with corticosteroids with significant improvement in symptoms and in calcium and creatinine levels. Besides, the patient presented a long-term large joints arthropathy, especially on the knees (with bilateral prosthesis), wrists, and ankles, of unknown etiology. We discuss the systemic manifestations of sarcoidosis related to the reported case, as well as the possible overlapping of idiopathic juvenile arthritis with sarcoidosis. |
| format | Article |
| id | doaj-art-af5c3a94e7104797b64f65890dd2b8a4 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-af5c3a94e7104797b64f65890dd2b8a42025-02-03T06:45:57ZengWileyCase Reports in Rheumatology2090-68892090-68972019-01-01201910.1155/2019/64832456483245Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and SarcoidosisMatheus Campello Vieira0Priscilla Gomes Tosta1Fernanda Morello Nicole2Lucas Enock V. Roberto3Júlia Guasti P. Vianna4Paulo de Coelho Castro5Rafael Burgomeister Lourenço6Erica Vieira Serrano7Valéria Valim8Weverton Machado Luchi9Federal University of Espírito Santo (UFES), Vitória, ES, BrazilFederal University of Espírito Santo (UFES), Vitória, ES, BrazilCassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilFederal University of Espírito Santo (UFES), Vitória, ES, BrazilCassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilFederal University of Espírito Santo (UFES), Vitória, ES, BrazilRadiology Service, Cassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilRheumatology Service, Cassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilRheumatology Service, Cassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilNephrology Service, Cassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, BrazilSarcoidosis is a multisystem disease with unknown etiology, marked by T lymphocytes and macrophages agglomeration, which leads to the formation of noncaseating granulomas in the affected tissues. We describe a case of a 40-year-old black patient referred to our service for evaluation of nephrolithiasis and persistent elevation of plasma creatinine. He reported important weight loss, fever episodes, and abdominal and low back intermittent pain in the past 6 months. The investigation revealed elevated serum calcium level, hepatosplenomegaly, retroperitoneal lymphadenopathy, anemia, thrombocytopenia, and nephrolithiasis. The initial diagnostic hypothesis was lymphoproliferative disease, but the laparoscopic propaedeutic showed multiple white lesions on the liver surface, which biopsy identified as noncaseating granulomas with asteroid corpuscles, suggestive of sarcoidosis. He was treated with corticosteroids with significant improvement in symptoms and in calcium and creatinine levels. Besides, the patient presented a long-term large joints arthropathy, especially on the knees (with bilateral prosthesis), wrists, and ankles, of unknown etiology. We discuss the systemic manifestations of sarcoidosis related to the reported case, as well as the possible overlapping of idiopathic juvenile arthritis with sarcoidosis.http://dx.doi.org/10.1155/2019/6483245 |
| spellingShingle | Matheus Campello Vieira Priscilla Gomes Tosta Fernanda Morello Nicole Lucas Enock V. Roberto Júlia Guasti P. Vianna Paulo de Coelho Castro Rafael Burgomeister Lourenço Erica Vieira Serrano Valéria Valim Weverton Machado Luchi Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis Case Reports in Rheumatology |
| title | Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis |
| title_full | Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis |
| title_fullStr | Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis |
| title_full_unstemmed | Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis |
| title_short | Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis |
| title_sort | chronic inflammatory arthropathy preceding acute systemic manifestations of sarcoidosis a possible overlap of idiopathic juvenile arthritis and sarcoidosis |
| url | http://dx.doi.org/10.1155/2019/6483245 |
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