Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly
ABSTRACT Purpose The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention‐deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits....
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2025-01-01
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| Online Access: | https://doi.org/10.1002/brb3.70255 |
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| author | Andrea Urru Oualid Benkarim Gerard Martí‐Juan Nadine Hahner Gemma Piella Elisenda Eixarch Miguel A. González Ballester |
| author_facet | Andrea Urru Oualid Benkarim Gerard Martí‐Juan Nadine Hahner Gemma Piella Elisenda Eixarch Miguel A. González Ballester |
| author_sort | Andrea Urru |
| collection | DOAJ |
| description | ABSTRACT Purpose The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention‐deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some studies have also shown a relationship between VM and cortical overgrowth, along with reduced cortical folding, both in fetuses and neonates. However, there is a lack of longitudinal studies that study this relationship from fetuses to neonates. Method We used a longitudinal dataset of 30 subjects (15 healthy controls and 15 subjects diagnosed with isolated non‐severe VM (INSVM)) with structural MRI acquired in and ex utero for each subject. We focused on the impact of fetal INSVM on cortical development from a longitudinal perspective, from the fetal to the neonatal stage. Particularly, we examined the relationship between ventricular enlargement and both volumetric features and a multifaceted set of cortical folding measures, including local gyrification, sulcal depth, curvature, and cortical thickness. Findings Our results show significant effects of isolated non‐severe VM (INSVM) compared to healthy controls, with reduced cortical thickness in specific brain regions such as the occipital, parietal, and frontal lobes. Conclusion These findings align with existing literature, confirming the presence of alterations in cortical growth and folding in subjects with isolated non‐severe VM (INSVM) from the fetal to neonatal stage compared to controls. |
| format | Article |
| id | doaj-art-af53efdc87274eb6bb878bea75397e45 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-af53efdc87274eb6bb878bea75397e452025-01-29T13:36:40ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70255Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe VentriculomegalyAndrea Urru0Oualid Benkarim1Gerard Martí‐Juan2Nadine Hahner3Gemma Piella4Elisenda Eixarch5Miguel A. González Ballester6BCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra Barcelona SpainMcConnell Brain Imaging Centre Montreal Neurological Institute and Hospital, McGill University Montreal Quebec CanadaBCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra Barcelona SpainBCNatal Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu) University of Barcelona Barcelona SpainBCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra Barcelona SpainBCNatal Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu) University of Barcelona Barcelona SpainBCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra Barcelona SpainABSTRACT Purpose The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention‐deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some studies have also shown a relationship between VM and cortical overgrowth, along with reduced cortical folding, both in fetuses and neonates. However, there is a lack of longitudinal studies that study this relationship from fetuses to neonates. Method We used a longitudinal dataset of 30 subjects (15 healthy controls and 15 subjects diagnosed with isolated non‐severe VM (INSVM)) with structural MRI acquired in and ex utero for each subject. We focused on the impact of fetal INSVM on cortical development from a longitudinal perspective, from the fetal to the neonatal stage. Particularly, we examined the relationship between ventricular enlargement and both volumetric features and a multifaceted set of cortical folding measures, including local gyrification, sulcal depth, curvature, and cortical thickness. Findings Our results show significant effects of isolated non‐severe VM (INSVM) compared to healthy controls, with reduced cortical thickness in specific brain regions such as the occipital, parietal, and frontal lobes. Conclusion These findings align with existing literature, confirming the presence of alterations in cortical growth and folding in subjects with isolated non‐severe VM (INSVM) from the fetal to neonatal stage compared to controls.https://doi.org/10.1002/brb3.70255atlas‐based segmentation | brain | fetal | longitudinal analysis | mixed‐effects model | MRI | neonatal | ventriculomegaly |
| spellingShingle | Andrea Urru Oualid Benkarim Gerard Martí‐Juan Nadine Hahner Gemma Piella Elisenda Eixarch Miguel A. González Ballester Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly Brain and Behavior atlas‐based segmentation | brain | fetal | longitudinal analysis | mixed‐effects model | MRI | neonatal | ventriculomegaly |
| title | Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly |
| title_full | Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly |
| title_fullStr | Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly |
| title_full_unstemmed | Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly |
| title_short | Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly |
| title_sort | longitudinal assessment of abnormal cortical folding in fetuses and neonates with isolated non severe ventriculomegaly |
| topic | atlas‐based segmentation | brain | fetal | longitudinal analysis | mixed‐effects model | MRI | neonatal | ventriculomegaly |
| url | https://doi.org/10.1002/brb3.70255 |
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