The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity
While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/149516 |
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| author | B. Gwen Windham Stefano Fumagalli Alessandro Ble John J. Sollers Julian F. Thayer Samar S. Najjar Michael E. Griswold Luigi Ferrucci |
| author_facet | B. Gwen Windham Stefano Fumagalli Alessandro Ble John J. Sollers Julian F. Thayer Samar S. Najjar Michael E. Griswold Luigi Ferrucci |
| author_sort | B. Gwen Windham |
| collection | DOAJ |
| description | While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; therefore, centrally distributed adipose tissue, that is, waist circumference (WC), should be more strongly associated with HRV than overall adiposity (BMI). To examine this hypothesis, we used data collected in a subset of the Baltimore Longitudinal Study of Aging to compare strength of association between HRV and WC to that of HRV and BMI. Time domain HRV variables SDNN (standard deviation of successive differences in normal-to-normal (N-N) intervals) and RMSSD (root mean square of successive differences in N-N intervals) were calculated from 24-hour Holter recordings in 159 participants (29–96 years). Increasing WC was associated with decreasing SDNN and RMSSD in younger but not older participants (P value for WC-by-age interaction = 0.003). BMI was not associated with either SDNN or RMSSD at any age. In conclusion, central adiposity may contribute to sympathetic and parasympathetic ANS declines early in life. |
| format | Article |
| id | doaj-art-af4f58ffde8f45a98b4406621c00e371 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-af4f58ffde8f45a98b4406621c00e3712025-02-03T06:07:49ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/149516149516The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall AdiposityB. Gwen Windham0Stefano Fumagalli1Alessandro Ble2John J. Sollers3Julian F. Thayer4Samar S. Najjar5Michael E. Griswold6Luigi Ferrucci7Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USAUnit of Geriatrics, Department of Critical Care Medicine and Surgery, University of Florence and AOU Careggi, 50134 Florence, ItalyClinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225-1290, USADepartment of Psychological Medicine, Faculty of Medical & Health Science, The University of Auckland, Auckland 1142, New ZealandThe Ohio State University, Columbus, OH 43210, USAClinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225-1290, USACenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS 39216, USAClinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225-1290, USAWhile frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. We hypothesized that effects of adiposity on ANS are mostly mediated by visceral fat and less by subcutaneous fat; therefore, centrally distributed adipose tissue, that is, waist circumference (WC), should be more strongly associated with HRV than overall adiposity (BMI). To examine this hypothesis, we used data collected in a subset of the Baltimore Longitudinal Study of Aging to compare strength of association between HRV and WC to that of HRV and BMI. Time domain HRV variables SDNN (standard deviation of successive differences in normal-to-normal (N-N) intervals) and RMSSD (root mean square of successive differences in N-N intervals) were calculated from 24-hour Holter recordings in 159 participants (29–96 years). Increasing WC was associated with decreasing SDNN and RMSSD in younger but not older participants (P value for WC-by-age interaction = 0.003). BMI was not associated with either SDNN or RMSSD at any age. In conclusion, central adiposity may contribute to sympathetic and parasympathetic ANS declines early in life.http://dx.doi.org/10.1155/2012/149516 |
| spellingShingle | B. Gwen Windham Stefano Fumagalli Alessandro Ble John J. Sollers Julian F. Thayer Samar S. Najjar Michael E. Griswold Luigi Ferrucci The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity Journal of Obesity |
| title | The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity |
| title_full | The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity |
| title_fullStr | The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity |
| title_full_unstemmed | The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity |
| title_short | The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity |
| title_sort | relationship between heart rate variability and adiposity differs for central and overall adiposity |
| url | http://dx.doi.org/10.1155/2012/149516 |
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