Natural Products: Insights into Leishmaniasis Inflammatory Response
Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous me...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/835910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564985097617408 |
|---|---|
| author | Igor A. Rodrigues Ana Maria Mazotto Verônica Cardoso Renan L. Alves Ana Claudia F. Amaral Jefferson Rocha de Andrade Silva Anderson S. Pinheiro Alane B. Vermelho |
| author_facet | Igor A. Rodrigues Ana Maria Mazotto Verônica Cardoso Renan L. Alves Ana Claudia F. Amaral Jefferson Rocha de Andrade Silva Anderson S. Pinheiro Alane B. Vermelho |
| author_sort | Igor A. Rodrigues |
| collection | DOAJ |
| description | Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs. Despite the relevance of host inflammatory mediators on parasite burden control, Leishmania and host immune cells interaction may generate an exacerbated proinflammatory response that plays an important role in the development of leishmaniasis clinical manifestations. Plant-derived natural products have been recognized as bioactive agents with several properties, including anti-protozoal and anti-inflammatory activities. The present review focuses on the antileishmanial activity of plant-derived natural products that are able to modulate the inflammatory response in vitro and in vivo. The capability of crude extracts and some isolated substances in promoting an anti-inflammatory response during Leishmania infection may be used as part of an effective strategy to fight the disease. |
| format | Article |
| id | doaj-art-af3e9ac10fae42aaa2552abeecb876bd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-af3e9ac10fae42aaa2552abeecb876bd2025-02-03T01:09:42ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/835910835910Natural Products: Insights into Leishmaniasis Inflammatory ResponseIgor A. Rodrigues0Ana Maria Mazotto1Verônica Cardoso2Renan L. Alves3Ana Claudia F. Amaral4Jefferson Rocha de Andrade Silva5Anderson S. Pinheiro6Alane B. Vermelho7Departamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilPrograma de Pos-Graduação em Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilDepartamento de Produtos Naturais, Farmanguinhos, FIOCRUZ, 21041-250 Rio de Janeiro, RJ, BrazilDepartamento de Química, Universidade Federal do Amazonas, Japiim, 69077-000 Manaus, AM, BrazilPrograma de Pos-Graduação em Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilDepartamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilLeishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs. Despite the relevance of host inflammatory mediators on parasite burden control, Leishmania and host immune cells interaction may generate an exacerbated proinflammatory response that plays an important role in the development of leishmaniasis clinical manifestations. Plant-derived natural products have been recognized as bioactive agents with several properties, including anti-protozoal and anti-inflammatory activities. The present review focuses on the antileishmanial activity of plant-derived natural products that are able to modulate the inflammatory response in vitro and in vivo. The capability of crude extracts and some isolated substances in promoting an anti-inflammatory response during Leishmania infection may be used as part of an effective strategy to fight the disease.http://dx.doi.org/10.1155/2015/835910 |
| spellingShingle | Igor A. Rodrigues Ana Maria Mazotto Verônica Cardoso Renan L. Alves Ana Claudia F. Amaral Jefferson Rocha de Andrade Silva Anderson S. Pinheiro Alane B. Vermelho Natural Products: Insights into Leishmaniasis Inflammatory Response Mediators of Inflammation |
| title | Natural Products: Insights into Leishmaniasis Inflammatory Response |
| title_full | Natural Products: Insights into Leishmaniasis Inflammatory Response |
| title_fullStr | Natural Products: Insights into Leishmaniasis Inflammatory Response |
| title_full_unstemmed | Natural Products: Insights into Leishmaniasis Inflammatory Response |
| title_short | Natural Products: Insights into Leishmaniasis Inflammatory Response |
| title_sort | natural products insights into leishmaniasis inflammatory response |
| url | http://dx.doi.org/10.1155/2015/835910 |
| work_keys_str_mv | AT igorarodrigues naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT anamariamazotto naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT veronicacardoso naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT renanlalves naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT anaclaudiafamaral naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT jeffersonrochadeandradesilva naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT andersonspinheiro naturalproductsinsightsintoleishmaniasisinflammatoryresponse AT alanebvermelho naturalproductsinsightsintoleishmaniasisinflammatoryresponse |