Adipocytokine Associations with Insulin Resistance in British South Asians
Aims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF-α and assessed the contribution of these molecules to insulin resistance in south Asians. H...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/561016 |
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| _version_ | 1832546008265916416 |
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| author | D. R. Webb K. Khunti S. Chatterjee J. Jarvis M. J. Davies |
| author_facet | D. R. Webb K. Khunti S. Chatterjee J. Jarvis M. J. Davies |
| author_sort | D. R. Webb |
| collection | DOAJ |
| description | Aims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF-α and assessed the contribution of these molecules to insulin resistance in south Asians.
Hypothesis. South Asians have adverse adipocytokine profiles which associate with an HOMA-derived insulin resistance phenotype.
Methods. We measured adipocytokine concentrations in south Asians with newly diagnosed impaired glucose tolerance or Type 2 Diabetes Mellitus in a case-control study. 158 (48.5% males) volunteers aged 25–75 years with risk factors for diabetes but no known vascular or metabolic disease provided serum samples for ELISA and bioplex assays.
Results. Total adiponectin concentration progressively decreased across the glucose spectrum in both sexes. A reciprocal trend in leptin concentration was observed only in south Asian men. Adiponectin but not leptin independently associated with HOMA-derived insulin resistance after logistic multivariate regression.
Conclusion. Diasporic south Asian populations have an adverse adipocytokine profile which deteriorates further with glucose dysregulation. Insulin resistance is inversely associated with adiponectin independent of BMI and waist circumference in south Asians, implying that adipocytokine interplay contributes to the pathogenesis of metabolic disease in this group. |
| format | Article |
| id | doaj-art-af3d43f3456d44f78f9edd1c0d91c4b4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-af3d43f3456d44f78f9edd1c0d91c4b42025-02-03T07:24:11ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/561016561016Adipocytokine Associations with Insulin Resistance in British South AsiansD. R. Webb0K. Khunti1S. Chatterjee2J. Jarvis3M. J. Davies4Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UKLeicester Diabetes Center, Leicester General Hospital, Ward 5 (Broadleaf), Gwendolen Road, Leicester LE5 4PW, UKBuckinghamshire Hospitals NHS Trust, Buckinghamshire HP7 OJD, UKLeicester Diabetes Center, Leicester General Hospital, Ward 5 (Broadleaf), Gwendolen Road, Leicester LE5 4PW, UKDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UKAims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF-α and assessed the contribution of these molecules to insulin resistance in south Asians. Hypothesis. South Asians have adverse adipocytokine profiles which associate with an HOMA-derived insulin resistance phenotype. Methods. We measured adipocytokine concentrations in south Asians with newly diagnosed impaired glucose tolerance or Type 2 Diabetes Mellitus in a case-control study. 158 (48.5% males) volunteers aged 25–75 years with risk factors for diabetes but no known vascular or metabolic disease provided serum samples for ELISA and bioplex assays. Results. Total adiponectin concentration progressively decreased across the glucose spectrum in both sexes. A reciprocal trend in leptin concentration was observed only in south Asian men. Adiponectin but not leptin independently associated with HOMA-derived insulin resistance after logistic multivariate regression. Conclusion. Diasporic south Asian populations have an adverse adipocytokine profile which deteriorates further with glucose dysregulation. Insulin resistance is inversely associated with adiponectin independent of BMI and waist circumference in south Asians, implying that adipocytokine interplay contributes to the pathogenesis of metabolic disease in this group.http://dx.doi.org/10.1155/2013/561016 |
| spellingShingle | D. R. Webb K. Khunti S. Chatterjee J. Jarvis M. J. Davies Adipocytokine Associations with Insulin Resistance in British South Asians Journal of Diabetes Research |
| title | Adipocytokine Associations with Insulin Resistance in British South Asians |
| title_full | Adipocytokine Associations with Insulin Resistance in British South Asians |
| title_fullStr | Adipocytokine Associations with Insulin Resistance in British South Asians |
| title_full_unstemmed | Adipocytokine Associations with Insulin Resistance in British South Asians |
| title_short | Adipocytokine Associations with Insulin Resistance in British South Asians |
| title_sort | adipocytokine associations with insulin resistance in british south asians |
| url | http://dx.doi.org/10.1155/2013/561016 |
| work_keys_str_mv | AT drwebb adipocytokineassociationswithinsulinresistanceinbritishsouthasians AT kkhunti adipocytokineassociationswithinsulinresistanceinbritishsouthasians AT schatterjee adipocytokineassociationswithinsulinresistanceinbritishsouthasians AT jjarvis adipocytokineassociationswithinsulinresistanceinbritishsouthasians AT mjdavies adipocytokineassociationswithinsulinresistanceinbritishsouthasians |