Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats
In the present study, we investigated the potential beneficial impact of the addition of antioxidant supplements to diclofenac regimen in a model of carrageenan-induced paw. Rats were treated daily with antioxidants, that is, a-lipoic acid (50 mg/kg), selenium (2.5 mg/kg), vitamin C (1 g/kg), vitami...
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| Language: | English |
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2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/731462 |
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| author | Samah S. Abbas Mona F. Schaalan Ashraf K. Bahgat Ezzeddin S. El-Denshary |
| author_facet | Samah S. Abbas Mona F. Schaalan Ashraf K. Bahgat Ezzeddin S. El-Denshary |
| author_sort | Samah S. Abbas |
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| description | In the present study, we investigated the potential beneficial impact of the addition of antioxidant supplements to diclofenac regimen in a model of carrageenan-induced paw. Rats were treated daily with antioxidants, that is, a-lipoic acid (50 mg/kg), selenium (2.5 mg/kg), vitamin C (1 g/kg), vitamin E (300 mg/kg), or zinc (25 mg/kg) on seven successive days and then received a single treatment with diclofenac or saline before carrageenan was injected to induce paw inflammation. The results indicated that these combinations did not significantly affect the percentage inhibition of paw edema caused by diclofenac alone; however, some combination treatments ameliorated signs of concomitant oxidative stress (such as alterations in plasma malondialdehyde (MDA) levels, hemolysate reduced glutathione levels, and erythrocytic superoxide dismutase enzyme activities) imparted by diclofenac alone. In some cases, few tested antioxidants in combination with diclofenac resulted in increased plasma levels of interleukin- (IL-) 6 and C-reactive protein (CRP). In conclusion, the results of these studies suggested to us that the added presence of natural antioxidants could be beneficial as standard anti-inflammatory therapeutics for a patient under diclofenac treatment, albeit that these effects do not appear to significantly build upon those that could be obtained from this common anti-inflammatory agent per se. |
| format | Article |
| id | doaj-art-af2abe2bcf6e4b02b401eca3872b3337 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-af2abe2bcf6e4b02b401eca3872b33372025-02-03T01:10:23ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/731462731462Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in RatsSamah S. Abbas0Mona F. Schaalan1Ashraf K. Bahgat2Ezzeddin S. El-Denshary3Department of Pharmacology and Toxicology, Misr International University (MIU), Km 28, Cairo-Ismailia Road, P.O. Box 1, Heliopolis, Cairo, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Misr International University (MIU), Km 28, Cairo-Ismailia Road, P.O. Box 1, Heliopolis, Cairo, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, EgyptIn the present study, we investigated the potential beneficial impact of the addition of antioxidant supplements to diclofenac regimen in a model of carrageenan-induced paw. Rats were treated daily with antioxidants, that is, a-lipoic acid (50 mg/kg), selenium (2.5 mg/kg), vitamin C (1 g/kg), vitamin E (300 mg/kg), or zinc (25 mg/kg) on seven successive days and then received a single treatment with diclofenac or saline before carrageenan was injected to induce paw inflammation. The results indicated that these combinations did not significantly affect the percentage inhibition of paw edema caused by diclofenac alone; however, some combination treatments ameliorated signs of concomitant oxidative stress (such as alterations in plasma malondialdehyde (MDA) levels, hemolysate reduced glutathione levels, and erythrocytic superoxide dismutase enzyme activities) imparted by diclofenac alone. In some cases, few tested antioxidants in combination with diclofenac resulted in increased plasma levels of interleukin- (IL-) 6 and C-reactive protein (CRP). In conclusion, the results of these studies suggested to us that the added presence of natural antioxidants could be beneficial as standard anti-inflammatory therapeutics for a patient under diclofenac treatment, albeit that these effects do not appear to significantly build upon those that could be obtained from this common anti-inflammatory agent per se.http://dx.doi.org/10.1155/2014/731462 |
| spellingShingle | Samah S. Abbas Mona F. Schaalan Ashraf K. Bahgat Ezzeddin S. El-Denshary Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats The Scientific World Journal |
| title | Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats |
| title_full | Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats |
| title_fullStr | Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats |
| title_full_unstemmed | Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats |
| title_short | Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats |
| title_sort | possible potentiation by certain antioxidants of the anti inflammatory effects of diclofenac in rats |
| url | http://dx.doi.org/10.1155/2014/731462 |
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