Behavioral assessment of hippocampal function following dietary intervention
Pattern separation keeps items distinct in memory and is mediated by the hippocampus. A relationship between hippocampal function and diet quality has been suggested by findings in both humans and animals. In the present study, rats were fed over seven generations a diet containing increased amounts...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2018-09-01
|
| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453018300375 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569068827181056 |
|---|---|
| author | Klaus W. Lange Ewelina Stollberg Yukiko Nakamura Joachim Hauser |
| author_facet | Klaus W. Lange Ewelina Stollberg Yukiko Nakamura Joachim Hauser |
| author_sort | Klaus W. Lange |
| collection | DOAJ |
| description | Pattern separation keeps items distinct in memory and is mediated by the hippocampus. A relationship between hippocampal function and diet quality has been suggested by findings in both humans and animals. In the present study, rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids, reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids (“Western” diet). Spatial pattern separation (or local discrimination) performance of these animals was compared with that of rats fed a standard diet. A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task, with rats of the “Western” group performing fewer discriminations. The present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a “Western” diet. Future studies should determine which components of this diet induce the memory impairments related to the hippocampus. The translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated. Keywords: Memory, Hippocampus, Western diet, Fatty acids, Sugar |
| format | Article |
| id | doaj-art-af2a88abb35f4d5ba0d82e9713484af4 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-af2a88abb35f4d5ba0d82e9713484af42025-02-02T23:24:49ZengTsinghua University PressFood Science and Human Wellness2213-45302018-09-0173229233Behavioral assessment of hippocampal function following dietary interventionKlaus W. Lange0Ewelina Stollberg1Yukiko Nakamura2Joachim Hauser3Corresponding author: Institute of Psychology, University of Regensburg, 93040 Regensburg, Germany.; Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyPattern separation keeps items distinct in memory and is mediated by the hippocampus. A relationship between hippocampal function and diet quality has been suggested by findings in both humans and animals. In the present study, rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids, reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids (“Western” diet). Spatial pattern separation (or local discrimination) performance of these animals was compared with that of rats fed a standard diet. A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task, with rats of the “Western” group performing fewer discriminations. The present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a “Western” diet. Future studies should determine which components of this diet induce the memory impairments related to the hippocampus. The translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated. Keywords: Memory, Hippocampus, Western diet, Fatty acids, Sugarhttp://www.sciencedirect.com/science/article/pii/S2213453018300375 |
| spellingShingle | Klaus W. Lange Ewelina Stollberg Yukiko Nakamura Joachim Hauser Behavioral assessment of hippocampal function following dietary intervention Food Science and Human Wellness |
| title | Behavioral assessment of hippocampal function following dietary intervention |
| title_full | Behavioral assessment of hippocampal function following dietary intervention |
| title_fullStr | Behavioral assessment of hippocampal function following dietary intervention |
| title_full_unstemmed | Behavioral assessment of hippocampal function following dietary intervention |
| title_short | Behavioral assessment of hippocampal function following dietary intervention |
| title_sort | behavioral assessment of hippocampal function following dietary intervention |
| url | http://www.sciencedirect.com/science/article/pii/S2213453018300375 |
| work_keys_str_mv | AT klauswlange behavioralassessmentofhippocampalfunctionfollowingdietaryintervention AT ewelinastollberg behavioralassessmentofhippocampalfunctionfollowingdietaryintervention AT yukikonakamura behavioralassessmentofhippocampalfunctionfollowingdietaryintervention AT joachimhauser behavioralassessmentofhippocampalfunctionfollowingdietaryintervention |