Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura
Introduction. Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder that causes decreased production and destruction of platelets leading to thrombocytopenia. Although thrombocytopenia usually causes hemorrhagic problems, thrombotic events like strokes, although rare, can sti...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/3184346 |
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| author | Zakaria Hindi Nirmal Onteddu Christopher A. Ching Abdallah A. Khaled |
| author_facet | Zakaria Hindi Nirmal Onteddu Christopher A. Ching Abdallah A. Khaled |
| author_sort | Zakaria Hindi |
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| description | Introduction. Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder that causes decreased production and destruction of platelets leading to thrombocytopenia. Although thrombocytopenia usually causes hemorrhagic problems, thrombotic events like strokes, although rare, can still occur. Management of thrombotic events in patients with ITP differs from that of patients with normal platelet count function and count. Case Description. A 32-year-old female with a history of ITP presented with ischemic stroke. The patient was treated in the hospital with IV immunoglobulin, discharged to a rehabilitation facility, and had complete resolution of symptoms when examined at a follow-up visit 3 months later. Conclusion. Although stroke in patients with ITP is very rare due to thrombocytopenia, it has been reported in several other published cases and is likely associated with increased platelet microparticle levels, a byproduct of platelet destruction. While usage of antiplatelet therapy in such patients is debated, immunosuppression therapy has been the mainstay treatment in all published cases. |
| format | Article |
| id | doaj-art-af26962fe8a94c2286122a5e0b8487d0 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-af26962fe8a94c2286122a5e0b8487d02025-02-03T01:01:08ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/31843463184346Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic PurpuraZakaria Hindi0Nirmal Onteddu1Christopher A. Ching2Abdallah A. Khaled3Department of Internal Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USADepartment of Internal Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USASchool of Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USASchool of Medicine, University of Jordan, Amman, JordanIntroduction. Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder that causes decreased production and destruction of platelets leading to thrombocytopenia. Although thrombocytopenia usually causes hemorrhagic problems, thrombotic events like strokes, although rare, can still occur. Management of thrombotic events in patients with ITP differs from that of patients with normal platelet count function and count. Case Description. A 32-year-old female with a history of ITP presented with ischemic stroke. The patient was treated in the hospital with IV immunoglobulin, discharged to a rehabilitation facility, and had complete resolution of symptoms when examined at a follow-up visit 3 months later. Conclusion. Although stroke in patients with ITP is very rare due to thrombocytopenia, it has been reported in several other published cases and is likely associated with increased platelet microparticle levels, a byproduct of platelet destruction. While usage of antiplatelet therapy in such patients is debated, immunosuppression therapy has been the mainstay treatment in all published cases.http://dx.doi.org/10.1155/2017/3184346 |
| spellingShingle | Zakaria Hindi Nirmal Onteddu Christopher A. Ching Abdallah A. Khaled Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura Case Reports in Hematology |
| title | Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura |
| title_full | Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura |
| title_fullStr | Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura |
| title_full_unstemmed | Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura |
| title_short | Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura |
| title_sort | vertebral artery thrombosis in chronic idiopathic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2017/3184346 |
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