Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women
BackgroundWomen are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis of gallbladder disease. This study aimed to assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term risk of chole...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1446271/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850270111517114368 |
|---|---|
| author | Guan-Jun Ding Wei Jiang Jie-Qiong Lyu Jie Ma Guo-Chong Chen Fu-Rong Li Si-Jia Yang Meng-Yuan Miao Yong-Fei Hua |
| author_facet | Guan-Jun Ding Wei Jiang Jie-Qiong Lyu Jie Ma Guo-Chong Chen Fu-Rong Li Si-Jia Yang Meng-Yuan Miao Yong-Fei Hua |
| author_sort | Guan-Jun Ding |
| collection | DOAJ |
| description | BackgroundWomen are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis of gallbladder disease. This study aimed to assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term risk of cholecystectomy in women.MethodsA total of 184,677 women were included from the UK Biobank. Multivariable Cox regression models were used to estimate the associations of menopausal characteristics and HRT with risk of cholecystectomy. The joint influence of HRT use and the status and type of menopause on incident cholecystectomy were further evaluated.ResultsDuring a median of 12.7 years of follow-up, 4,991 incident cases of cholecystectomy were identified. Natural menopause, regardless of menopausal age, was not associated with risk of cholecystectomy, while surgical menopause at a young age was associated with a higher risk of cholecystectomy. Ever use of HRT was associated with a higher risk of cholecystectomy. In particular, women who were surgically-menopausal and started HRT before menopause had the highest risk for cholecystectomy (hazard ratio = 2.28; 95% confidence interval: 1.70–3.04), when compared with women who were naturally-menopausal and never used HRT.ConclusionsEarly surgical menopause and ever use of HRT was independently associated with the risk of cholecystectomy. |
| format | Article |
| id | doaj-art-af24f17e208c4be99a56c88cceff9ff4 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-af24f17e208c4be99a56c88cceff9ff42025-08-20T01:52:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14462711446271Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in womenGuan-Jun Ding0Wei Jiang1Jie-Qiong Lyu2Jie Ma3Guo-Chong Chen4Fu-Rong Li5Si-Jia Yang6Meng-Yuan Miao7Yong-Fei Hua8The Second Department of General Surgery, Ningbo No. 9 Hospital, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, ChinaNingbo Municipal Center for Disease Control and Prevention, Ningbo, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Hepatopancreatobiliary Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, ChinaBackgroundWomen are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis of gallbladder disease. This study aimed to assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term risk of cholecystectomy in women.MethodsA total of 184,677 women were included from the UK Biobank. Multivariable Cox regression models were used to estimate the associations of menopausal characteristics and HRT with risk of cholecystectomy. The joint influence of HRT use and the status and type of menopause on incident cholecystectomy were further evaluated.ResultsDuring a median of 12.7 years of follow-up, 4,991 incident cases of cholecystectomy were identified. Natural menopause, regardless of menopausal age, was not associated with risk of cholecystectomy, while surgical menopause at a young age was associated with a higher risk of cholecystectomy. Ever use of HRT was associated with a higher risk of cholecystectomy. In particular, women who were surgically-menopausal and started HRT before menopause had the highest risk for cholecystectomy (hazard ratio = 2.28; 95% confidence interval: 1.70–3.04), when compared with women who were naturally-menopausal and never used HRT.ConclusionsEarly surgical menopause and ever use of HRT was independently associated with the risk of cholecystectomy.https://www.frontiersin.org/articles/10.3389/fmed.2024.1446271/fullcholecystectomygallbladder diseasehormone replacement therapymenopausal characteristicscohort study |
| spellingShingle | Guan-Jun Ding Wei Jiang Jie-Qiong Lyu Jie Ma Guo-Chong Chen Fu-Rong Li Si-Jia Yang Meng-Yuan Miao Yong-Fei Hua Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women Frontiers in Medicine cholecystectomy gallbladder disease hormone replacement therapy menopausal characteristics cohort study |
| title | Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women |
| title_full | Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women |
| title_fullStr | Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women |
| title_full_unstemmed | Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women |
| title_short | Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women |
| title_sort | menopausal characteristics and hormone replacement therapy in relation to long term risk of cholecystectomy in women |
| topic | cholecystectomy gallbladder disease hormone replacement therapy menopausal characteristics cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1446271/full |
| work_keys_str_mv | AT guanjunding menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT weijiang menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT jieqionglyu menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT jiema menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT guochongchen menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT furongli menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT sijiayang menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT mengyuanmiao menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen AT yongfeihua menopausalcharacteristicsandhormonereplacementtherapyinrelationtolongtermriskofcholecystectomyinwomen |