Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/9839348 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565465769050112 |
|---|---|
| author | Pedro Cisternas Paulina Salazar Carmen Silva-Álvarez L. Felipe Barros Nibaldo C. Inestrosa |
| author_facet | Pedro Cisternas Paulina Salazar Carmen Silva-Álvarez L. Felipe Barros Nibaldo C. Inestrosa |
| author_sort | Pedro Cisternas |
| collection | DOAJ |
| description | In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and energy metabolism. The brain has a high demand for glucose, which is mainly used for energy production. Neurons use energy for highly specific processes that require a high energy level, such as maintaining the electrical potential and synthesizing neurotransmitters. Moreover, an important metabolic impairment has been described in all neurodegenerative disorders. Despite the key role of glucose metabolism in the brain, little is known about the cellular pathways involved in regulating this process. We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide. Our data suggest that Wnt signaling stimulates neuronal glucose metabolism, an effect that could be important for the reported neuroprotective role of Wnt signaling in neurodegenerative disorders. |
| format | Article |
| id | doaj-art-af228b2a0a764eae85991f14f45bc368 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-af228b2a0a764eae85991f14f45bc3682025-02-03T01:07:46ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/98393489839348Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical NeuronsPedro Cisternas0Paulina Salazar1Carmen Silva-Álvarez2L. Felipe Barros3Nibaldo C. Inestrosa4CARE Biomedical Research Center, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Alameda 340, P.O. Box 114-D, Santiago, ChileCARE Biomedical Research Center, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Alameda 340, P.O. Box 114-D, Santiago, ChileCARE Biomedical Research Center, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Alameda 340, P.O. Box 114-D, Santiago, ChileCentro de Estudios Científicos (CECs), Casilla 1469, Valdivia, ChileCARE Biomedical Research Center, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Alameda 340, P.O. Box 114-D, Santiago, ChileIn the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and energy metabolism. The brain has a high demand for glucose, which is mainly used for energy production. Neurons use energy for highly specific processes that require a high energy level, such as maintaining the electrical potential and synthesizing neurotransmitters. Moreover, an important metabolic impairment has been described in all neurodegenerative disorders. Despite the key role of glucose metabolism in the brain, little is known about the cellular pathways involved in regulating this process. We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide. Our data suggest that Wnt signaling stimulates neuronal glucose metabolism, an effect that could be important for the reported neuroprotective role of Wnt signaling in neurodegenerative disorders.http://dx.doi.org/10.1155/2016/9839348 |
| spellingShingle | Pedro Cisternas Paulina Salazar Carmen Silva-Álvarez L. Felipe Barros Nibaldo C. Inestrosa Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons Neural Plasticity |
| title | Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons |
| title_full | Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons |
| title_fullStr | Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons |
| title_full_unstemmed | Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons |
| title_short | Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons |
| title_sort | wnt5a increases the glycolytic rate and the activity of the pentose phosphate pathway in cortical neurons |
| url | http://dx.doi.org/10.1155/2016/9839348 |
| work_keys_str_mv | AT pedrocisternas wnt5aincreasestheglycolyticrateandtheactivityofthepentosephosphatepathwayincorticalneurons AT paulinasalazar wnt5aincreasestheglycolyticrateandtheactivityofthepentosephosphatepathwayincorticalneurons AT carmensilvaalvarez wnt5aincreasestheglycolyticrateandtheactivityofthepentosephosphatepathwayincorticalneurons AT lfelipebarros wnt5aincreasestheglycolyticrateandtheactivityofthepentosephosphatepathwayincorticalneurons AT nibaldocinestrosa wnt5aincreasestheglycolyticrateandtheactivityofthepentosephosphatepathwayincorticalneurons |