Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production
Abstract Background Beyond the use of conventional short-lived PET radionuclides, there is a growing interest in tracking larger biomolecules and exploring radiotheranostic applications. One promising option for imaging medium-sized molecules and peptides is ⁵⁵Co (T₁/₂ = 17.5 h, β⁺ = 76%), which ena...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | EJNMMI Radiopharmacy and Chemistry |
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| Online Access: | https://doi.org/10.1186/s41181-024-00324-5 |
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| author | Jonathan Siikanen Stefan Milton Klas Bratteby Wilson Lin Jonathan W. Engle Emma Jussing Thuy A. Tran |
| author_facet | Jonathan Siikanen Stefan Milton Klas Bratteby Wilson Lin Jonathan W. Engle Emma Jussing Thuy A. Tran |
| author_sort | Jonathan Siikanen |
| collection | DOAJ |
| description | Abstract Background Beyond the use of conventional short-lived PET radionuclides, there is a growing interest in tracking larger biomolecules and exploring radiotheranostic applications. One promising option for imaging medium-sized molecules and peptides is ⁵⁵Co (T₁/₂ = 17.5 h, β⁺ = 76%), which enables imaging of new and already established tracers with blood circulation of several hours. Additionally, ⁵⁵Co can be paired with the Auger-Meitner emitter 58mCo (T₁/₂ = 9 h, 100% IC) for radiotheranostic applications. Here we report on 55Co production via the 58Ni(p,α)55Co reaction channel using pressed 58Ni and Mg matrix targets. Results This set up is capable to produce and isolate 240 ± 20 MBq [55Co]Co+ 2 (80% RCY) with 4 ml 0.25 M HEPES at 35 min post End Of Bombardment for 3 h, 25 µA protons irradiation. The RNP of the eluate is 99.98 ± 0.014% as measured 2 h & 17 h post EOB. AMA was determined to 1.5 ± 0.5 GBq/µmol [55Co]Co-DOTA at EOB. Mg dissolves rapidly in the acid mixture, leaving behind a porous, sponge-like Ni matrix increasing the surface area of the Ni and therefore accelerating the dissolution. Conclusion We present a novel, simple, and rapid method to produce ⁵⁵Co with pressed ⁵⁸Ni/Mg matrix targets enabling faster target fabrication and dissolution. By using a simple hydraulic press, mechanically stable target coins useful for solid target irradiation are fabricated within 5 min and can be dissolved in 10 min at room temperature. The foils remain intact after irradiation and can endure irradiation conditions providing sufficient activity (> 200 MBq) for clinical doses. The method presented here using Mg as a support metal for fixation of the actual target material into target coins is applicable for other target combinations as well. Using Mg as a support metal is suitable due to its thermal conductivity, low activation, minimal impact on purification chemistry, softness, ductility, and rapid dissolution in acid. |
| format | Article |
| id | doaj-art-af1c2f5ebbc3405a875edbd9e9a283a7 |
| institution | Kabale University |
| issn | 2365-421X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Radiopharmacy and Chemistry |
| spelling | doaj-art-af1c2f5ebbc3405a875edbd9e9a283a72025-01-26T12:58:26ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2025-01-0110111110.1186/s41181-024-00324-5Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co productionJonathan Siikanen0Stefan Milton1Klas Bratteby2Wilson Lin3Jonathan W. Engle4Emma Jussing5Thuy A. Tran6Department of Nuclear Medicine and Medical Physics, Karolinska University HospitalDepartment of Clinical Neurosciences, Karolinska InstitutetDepartment of Nuclear Medicine and Medical Physics, Karolinska University HospitalDepartment of Medical Physics, University of WisconsinDepartment of Medical Physics, University of WisconsinDepartment of Nuclear Medicine and Medical Physics, Karolinska University HospitalDepartment of Nuclear Medicine and Medical Physics, Karolinska University HospitalAbstract Background Beyond the use of conventional short-lived PET radionuclides, there is a growing interest in tracking larger biomolecules and exploring radiotheranostic applications. One promising option for imaging medium-sized molecules and peptides is ⁵⁵Co (T₁/₂ = 17.5 h, β⁺ = 76%), which enables imaging of new and already established tracers with blood circulation of several hours. Additionally, ⁵⁵Co can be paired with the Auger-Meitner emitter 58mCo (T₁/₂ = 9 h, 100% IC) for radiotheranostic applications. Here we report on 55Co production via the 58Ni(p,α)55Co reaction channel using pressed 58Ni and Mg matrix targets. Results This set up is capable to produce and isolate 240 ± 20 MBq [55Co]Co+ 2 (80% RCY) with 4 ml 0.25 M HEPES at 35 min post End Of Bombardment for 3 h, 25 µA protons irradiation. The RNP of the eluate is 99.98 ± 0.014% as measured 2 h & 17 h post EOB. AMA was determined to 1.5 ± 0.5 GBq/µmol [55Co]Co-DOTA at EOB. Mg dissolves rapidly in the acid mixture, leaving behind a porous, sponge-like Ni matrix increasing the surface area of the Ni and therefore accelerating the dissolution. Conclusion We present a novel, simple, and rapid method to produce ⁵⁵Co with pressed ⁵⁸Ni/Mg matrix targets enabling faster target fabrication and dissolution. By using a simple hydraulic press, mechanically stable target coins useful for solid target irradiation are fabricated within 5 min and can be dissolved in 10 min at room temperature. The foils remain intact after irradiation and can endure irradiation conditions providing sufficient activity (> 200 MBq) for clinical doses. The method presented here using Mg as a support metal for fixation of the actual target material into target coins is applicable for other target combinations as well. Using Mg as a support metal is suitable due to its thermal conductivity, low activation, minimal impact on purification chemistry, softness, ductility, and rapid dissolution in acid.https://doi.org/10.1186/s41181-024-00324-5Cyclotron55Co 58Ni/Mg-matrixSolid targetDOTAAMA |
| spellingShingle | Jonathan Siikanen Stefan Milton Klas Bratteby Wilson Lin Jonathan W. Engle Emma Jussing Thuy A. Tran Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production EJNMMI Radiopharmacy and Chemistry Cyclotron 55Co 58Ni/Mg-matrix Solid target DOTA AMA |
| title | Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production |
| title_full | Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production |
| title_fullStr | Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production |
| title_full_unstemmed | Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production |
| title_short | Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production |
| title_sort | rapid fabrication and dissolution of pressed 58ni mg matrix targets for 55co production |
| topic | Cyclotron 55Co 58Ni/Mg-matrix Solid target DOTA AMA |
| url | https://doi.org/10.1186/s41181-024-00324-5 |
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