A Systemic Network Triggered by Human Cytomegalovirus Entry
Virus entry is a multistep process that triggers various cellular pathways that interconnect into a complex network; yet the molecular complexity of this network remains largely elusive. Here, by employing systems biology approaches, we reveal a systemic virus-entry network initiated by human cytome...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/262080 |
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| _version_ | 1832552092633399296 |
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| author | Anyou Wang Li Ren Hong Li |
| author_facet | Anyou Wang Li Ren Hong Li |
| author_sort | Anyou Wang |
| collection | DOAJ |
| description | Virus entry is a multistep process that triggers various cellular pathways that interconnect into a complex network; yet the molecular complexity of this network remains largely elusive. Here, by employing systems biology approaches, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic pathogen. This network contains ten functional modules (i.e., groups of proteins) that coordinately respond to HCMV entry. Functional modules activated (up- and downregulated) in this network dramatically decline shortly within 25 minutes post infection. While modules annotated as receptor system, ion transport, and immune response are continuously activated during the entire process of HCMV entry, those annotated for cell adhesion and skeletal movement are specifically activated during viral early attachment. The up-regulated network contains various functional modules, such as cell surface receptors, skeletal development, endocytosis, ion transport, and chromatin remodeling. Interestingly, macromolecule metabolism and chromatin remodeling module predominates this over-expressed system, suggesting that the fundamental nuclear process modulation is one of the most important events in HCMV entry. The entire up-regulated network is primarily controlled by multiple elements like SLC10A1. Thus, virus entry triggers multiple cellular processes especially nuclear processes to facilitate its entry. |
| format | Article |
| id | doaj-art-af05a428297041b6823bd9ece306aea0 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-af05a428297041b6823bd9ece306aea02025-02-03T05:59:35ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/262080262080A Systemic Network Triggered by Human Cytomegalovirus EntryAnyou Wang0Li Ren1Hong Li2School of Public Health, University of California, Berkeley, CA 94720, USACenter for Clinical Investigation, School of Medicine, Stanford University, Stanford, CA 94305, USASchool of Public Health, University of California, Berkeley, CA 94720, USAVirus entry is a multistep process that triggers various cellular pathways that interconnect into a complex network; yet the molecular complexity of this network remains largely elusive. Here, by employing systems biology approaches, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic pathogen. This network contains ten functional modules (i.e., groups of proteins) that coordinately respond to HCMV entry. Functional modules activated (up- and downregulated) in this network dramatically decline shortly within 25 minutes post infection. While modules annotated as receptor system, ion transport, and immune response are continuously activated during the entire process of HCMV entry, those annotated for cell adhesion and skeletal movement are specifically activated during viral early attachment. The up-regulated network contains various functional modules, such as cell surface receptors, skeletal development, endocytosis, ion transport, and chromatin remodeling. Interestingly, macromolecule metabolism and chromatin remodeling module predominates this over-expressed system, suggesting that the fundamental nuclear process modulation is one of the most important events in HCMV entry. The entire up-regulated network is primarily controlled by multiple elements like SLC10A1. Thus, virus entry triggers multiple cellular processes especially nuclear processes to facilitate its entry.http://dx.doi.org/10.1155/2011/262080 |
| spellingShingle | Anyou Wang Li Ren Hong Li A Systemic Network Triggered by Human Cytomegalovirus Entry Advances in Virology |
| title | A Systemic Network Triggered by Human Cytomegalovirus Entry |
| title_full | A Systemic Network Triggered by Human Cytomegalovirus Entry |
| title_fullStr | A Systemic Network Triggered by Human Cytomegalovirus Entry |
| title_full_unstemmed | A Systemic Network Triggered by Human Cytomegalovirus Entry |
| title_short | A Systemic Network Triggered by Human Cytomegalovirus Entry |
| title_sort | systemic network triggered by human cytomegalovirus entry |
| url | http://dx.doi.org/10.1155/2011/262080 |
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