High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor
The specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes. To accurately distinguish the signal response caused by trace markers, the high demodulation resolution of the sensor is necessary. In this paper, we propose a dual-wavelength fiber laser...
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| Format: | Article |
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Institue of Optics and Electronics, Chinese Academy of Sciences
2024-12-01
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| Series: | Opto-Electronic Advances |
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| Online Access: | https://www.oejournal.org/article/doi/10.29026/oea.2024.240105 |
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| author | Jie Hu Weihao Lin Liyang Shao Chenlong Xue Fang Zhao Dongrui Xiao Yang Ran Yue Meng Panpan He Zhiguang Yu Jinna Chen Perry Ping Shum |
| author_facet | Jie Hu Weihao Lin Liyang Shao Chenlong Xue Fang Zhao Dongrui Xiao Yang Ran Yue Meng Panpan He Zhiguang Yu Jinna Chen Perry Ping Shum |
| author_sort | Jie Hu |
| collection | DOAJ |
| description | The specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes. To accurately distinguish the signal response caused by trace markers, the high demodulation resolution of the sensor is necessary. In this paper, we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics demodulation technology to achieve high-resolution tumor marker detection. This sensing system can simultaneously perform spectral wavelength-domain and frequency-domain analyses. Experimental results demonstrate that this system's refractive index (RI) sensitivity reaches 1083 nm/RIU by wavelength analysis and –1902 GHz/RIU by frequency analysis, with ideal detection resolutions of 1.85×10–5 RIU and 5.26×10–8 RIU, respectively. Compared with traditional wavelength domain analysis, the demodulation resolution is improved by three orders of magnitude, based on the same sensing structure. To validate its biosensing performance, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is selected as the detection target. Experimental results show that the improved sensing system has a limit of detection (LOD) of 0.076 ng/mL and a detection resolution of 0.008 ng/mL. Experimental results obtained from human serum samples are consistent with clinical data, highlighting the strong clinical application potential of the proposed sensing system and analysis method. |
| format | Article |
| id | doaj-art-af01f0769ce64710b989de59ca2256e1 |
| institution | Kabale University |
| issn | 2096-4579 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Institue of Optics and Electronics, Chinese Academy of Sciences |
| record_format | Article |
| series | Opto-Electronic Advances |
| spelling | doaj-art-af01f0769ce64710b989de59ca2256e12025-01-24T06:20:29ZengInstitue of Optics and Electronics, Chinese Academy of SciencesOpto-Electronic Advances2096-45792024-12-0171211710.29026/oea.2024.240105OEA-2024-0105ShaoliyangHigh-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensorJie Hu0Weihao Lin1Liyang Shao2Chenlong Xue3Fang Zhao4Dongrui Xiao5Yang Ran6Yue Meng7Panpan He8Zhiguang Yu9Jinna Chen10Perry Ping Shum11Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaSchool of Electrical Information Engineering, Hunan Institute of Technology, Hengyang 421002, ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, ChinaDepartment of Clinical Laboratory, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 511436, ChinaMedcaptain Medical Technology Co., Ltd., Shenzhen 518055, ChinaMedcaptain Medical Technology Co., Ltd., Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen 518055, ChinaThe specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes. To accurately distinguish the signal response caused by trace markers, the high demodulation resolution of the sensor is necessary. In this paper, we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics demodulation technology to achieve high-resolution tumor marker detection. This sensing system can simultaneously perform spectral wavelength-domain and frequency-domain analyses. Experimental results demonstrate that this system's refractive index (RI) sensitivity reaches 1083 nm/RIU by wavelength analysis and –1902 GHz/RIU by frequency analysis, with ideal detection resolutions of 1.85×10–5 RIU and 5.26×10–8 RIU, respectively. Compared with traditional wavelength domain analysis, the demodulation resolution is improved by three orders of magnitude, based on the same sensing structure. To validate its biosensing performance, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is selected as the detection target. Experimental results show that the improved sensing system has a limit of detection (LOD) of 0.076 ng/mL and a detection resolution of 0.008 ng/mL. Experimental results obtained from human serum samples are consistent with clinical data, highlighting the strong clinical application potential of the proposed sensing system and analysis method.https://www.oejournal.org/article/doi/10.29026/oea.2024.240105optical fiber sensoroptical fiber lasermicrowave photonics demodulationhigh-resolution detectiontumor marker detection |
| spellingShingle | Jie Hu Weihao Lin Liyang Shao Chenlong Xue Fang Zhao Dongrui Xiao Yang Ran Yue Meng Panpan He Zhiguang Yu Jinna Chen Perry Ping Shum High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor Opto-Electronic Advances optical fiber sensor optical fiber laser microwave photonics demodulation high-resolution detection tumor marker detection |
| title | High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| title_full | High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| title_fullStr | High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| title_full_unstemmed | High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| title_short | High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| title_sort | high resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor |
| topic | optical fiber sensor optical fiber laser microwave photonics demodulation high-resolution detection tumor marker detection |
| url | https://www.oejournal.org/article/doi/10.29026/oea.2024.240105 |
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