Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis
In recent genome-wide association studies (GWAS), several polymorphic loci of the osteoprotegerin (OPG) gene were significantly associated with bone mineral density (BMD) and fractures in men over 50 years of age and postmenopausal women. The objective of our study was to search for associations of...
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| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2021-03-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/368 |
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| author | Bulat I. Yalaev Anton V. Tyurin Regina I. Mirgalieva Elza K. Khusnutdinova Rita I. Khusainova |
| author_facet | Bulat I. Yalaev Anton V. Tyurin Regina I. Mirgalieva Elza K. Khusnutdinova Rita I. Khusainova |
| author_sort | Bulat I. Yalaev |
| collection | DOAJ |
| description | In recent genome-wide association studies (GWAS), several polymorphic loci of the osteoprotegerin (OPG) gene were significantly associated with bone mineral density (BMD) and fractures in men over 50 years of age and postmenopausal women. The objective of our study was to search for associations of rs3102735, rs3134069, rs2073617, rs2073618, rs3102734 and rs7844539 of the OPG gene with the risk of osteoporotic fractures and the level of BMD in individual and comorbid conditions in men and women from the Volga-Ural region of Russia.
Material and Methods — 828 women and 496 men of various ethnic groups (Russians, Turks) were examined using two-energy x-ray absorptiometry (DEXA) in the femoral neck and lumbar spine. 1324 deoxyribonucleic acid (DNA) samples were genotyped using a fluorescent endpoint genotyping system, after that we searched for associations of these polymorphic loci with fractures and low BMD levels of various localizations.
As a result, there was a significant association of rs3134069 and rs3102734 with fractures in general and in the peripheral parts of the skeleton, as well as rs7844539 and rs3102734 in women and rs2073618 in men with low BMD. Another significant association of rs3102734 and rs2073618 with low bone mineral density in the femoral neck was found in both genders.
Conclusion — Polymorphic variants rs3134069, rs3102734, rs7844539 and rs3102734 are potential markers of the risk of osteoporetic fractures and the formation of low BMD in men and women from the Volga-Ural region of Russia. |
| format | Article |
| id | doaj-art-aeff4eb9bc1b4e35b08f30bcb358f5db |
| institution | OA Journals |
| issn | 2304-3415 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-aeff4eb9bc1b4e35b08f30bcb358f5db2025-08-20T02:32:03ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152021-03-01101e010110.15275/rusomj.2021.0101Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosisBulat I. YalaevAnton V. TyurinRegina I. MirgalievaElza K. KhusnutdinovaRita I. KhusainovaIn recent genome-wide association studies (GWAS), several polymorphic loci of the osteoprotegerin (OPG) gene were significantly associated with bone mineral density (BMD) and fractures in men over 50 years of age and postmenopausal women. The objective of our study was to search for associations of rs3102735, rs3134069, rs2073617, rs2073618, rs3102734 and rs7844539 of the OPG gene with the risk of osteoporotic fractures and the level of BMD in individual and comorbid conditions in men and women from the Volga-Ural region of Russia. Material and Methods — 828 women and 496 men of various ethnic groups (Russians, Turks) were examined using two-energy x-ray absorptiometry (DEXA) in the femoral neck and lumbar spine. 1324 deoxyribonucleic acid (DNA) samples were genotyped using a fluorescent endpoint genotyping system, after that we searched for associations of these polymorphic loci with fractures and low BMD levels of various localizations. As a result, there was a significant association of rs3134069 and rs3102734 with fractures in general and in the peripheral parts of the skeleton, as well as rs7844539 and rs3102734 in women and rs2073618 in men with low BMD. Another significant association of rs3102734 and rs2073618 with low bone mineral density in the femoral neck was found in both genders. Conclusion — Polymorphic variants rs3134069, rs3102734, rs7844539 and rs3102734 are potential markers of the risk of osteoporetic fractures and the formation of low BMD in men and women from the Volga-Ural region of Russia.https://romj.org/node/368osteoporosispolymorphismosteoprotegeringenegenotyping |
| spellingShingle | Bulat I. Yalaev Anton V. Tyurin Regina I. Mirgalieva Elza K. Khusnutdinova Rita I. Khusainova Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis Russian Open Medical Journal osteoporosis polymorphism osteoprotegerin gene genotyping |
| title | Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| title_full | Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| title_fullStr | Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| title_full_unstemmed | Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| title_short | Investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| title_sort | investigating the role of osteoprotegerin gene polymorphic variants in osteoporosis |
| topic | osteoporosis polymorphism osteoprotegerin gene genotyping |
| url | https://romj.org/node/368 |
| work_keys_str_mv | AT bulatiyalaev investigatingtheroleofosteoprotegeringenepolymorphicvariantsinosteoporosis AT antonvtyurin investigatingtheroleofosteoprotegeringenepolymorphicvariantsinosteoporosis AT reginaimirgalieva investigatingtheroleofosteoprotegeringenepolymorphicvariantsinosteoporosis AT elzakkhusnutdinova investigatingtheroleofosteoprotegeringenepolymorphicvariantsinosteoporosis AT ritaikhusainova investigatingtheroleofosteoprotegeringenepolymorphicvariantsinosteoporosis |