Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a complex neurological disorder characterized by the progressive degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra (SN). This degeneration disrupts the basal ganglia loops, leading to both motor and non-motor dysfunctions. Cel...

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Bibliographic Details
Main Authors: Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Parkinson’s disease
Cell therapy
HiPSC
Intranigral transplantation
Mouse
Electrophysiology
Online Access:https://doi.org/10.1186/s13287-025-04344-z
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