Preparation of pH-Responsive Tanshinone IIA-Loaded Calcium Alginate Nanoparticles and Their Anticancer Mechanisms

Preparation of pH-Responsive Tanshinone IIA-Loaded Calcium Alginate Nanoparticles and Their Anticancer Mechanisms

<b>Background:</b> Tanshinone IIA (Tan IIA) is a lipophilic active constituent derived from the rhizomes and roots of <i>Salvia miltiorrhiza Bunge</i> (Danshen), a common Chinese medicinal herb. However, clinical applications of Tan IIA are limited due to its poor solubility...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tianying Ren, Jing Wang, Yingxin Ma, Yichen Huang, Somy Yoon, Lijun Mu, Ru Li, Xuekun Wang, Lina Zhang, Pan Li, Lusha Ji
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceutics
Subjects:	tanshinone IIA pH sensitive calcium alginate autophagy apoptosis cancer therapy
Online Access:	https://www.mdpi.com/1999-4923/17/1/66
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

NGHIÊN CỨU PHƯƠNG PHÁP PHÂN LẬP TANSHINONE IIA TỪ ĐAN SÂM LÀM CHẤT ĐỐI CHIẾU
by: Trịnh Thị Điệp, et al.
Published: (2015-03-01)

Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells
by: Linda Saxe Einbond, et al.
Published: (2024-12-01)

Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation
by: Wang Q, et al.
Published: (2025-01-01)

Sacrificing Alginate in Decellularized Extracellular Matrix Scaffolds for Implantable Artificial Livers
by: Chanh-Trung Nguyen, et al.
Published: (2025-01-01)

Bioadsorption of Copper(II) Using Halmahera Specific Marine Algae (<i>Sargassum turbinarioides</i>) Encapsulated Calcium Alginate
by: Dede Ardiansyah Takdir Abubakar Sanawi, et al.
Published: (2025-01-01)

Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease
by: O. A. Storonova, et al.
Published: (2018-11-01)

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads
by: Vlachou Marilena, et al.
Published: (2020-12-01)

Magnesium Alginate as an Electrolyte for Magnesium Batteries
by: Markus C. Kwakernaak, et al.
Published: (2025-01-01)

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice
by: Xin-Jing Yang, et al.
Published: (2018-01-01)

Progress in Research on Metal Ion Crosslinking Alginate-Based Gels
by: Yantao Wang, et al.
Published: (2024-12-01)

Encapsulated human islets in alginate fiber maintain long-term functionality
by: Junko Nishida, et al.
Published: (2024-03-01)

Effects of Calcium Chloride Crosslinking Solution Concentration on the Long-Term Cell Viability of 16HBE14o- Human Bronchial Cells Embedded in Alginate-Based Hydrogels
by: Nathan Wood, et al.
Published: (2025-01-01)

Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release
by: Marcus Flowers, et al.
Published: (2025-01-01)

Rheological Characterization and Printability of Sodium Alginate–Gelatin Hydrogel for 3D Cultures and Bioprinting
by: Mohan Kumar Dey, et al.
Published: (2025-01-01)

Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery
by: Cristina Mormile, et al.
Published: (2024-12-01)

Simultaneous Encapsulation of Probiotic Bacteria (<i>Lactococcus lactis</i>, and <i>Lactiplantibacillus plantarum</i>) in Calcium Alginate Hydrogels
by: Marko Vinceković, et al.
Published: (2025-01-01)

Performance of U(Ⅵ) enrichment by tannic acid sodium and alginate composite microspheres
by: LIU Qing, et al.
Published: (2025-01-01)

Citrus Soil pH Management
by: Kelly Morgan
Published: (2019-12-01)

Citrus Soil pH Management
by: Kelly Morgan
Published: (2019-12-01)

Citrus Soil pH Testing Procedures
by: Kelly Morgan
Published: (2019-12-01)

Citrus Soil pH Testing Procedures
by: Kelly Morgan
Published: (2019-12-01)

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
by: Szekalska Marta, et al.
Published: (2015-03-01)

CuO-Fe2O3/calcium alginate-carboxymethylcellulose-chitosan as efficient nanocomposite beads for catalytic reduction of water pollutants
by: Nujud Maslamani, et al.
Published: (2025-01-01)

Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss)
by: Samira Salarvand, et al.
Published: (2025-03-01)

Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100
by: Maghraby Gamal Mohamed El, et al.
Published: (2014-03-01)

SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate
by: Ni Putu Fiona Cista Dewi, et al.
Published: (2024-12-01)

Smart Zinc-Based Coatings with Chitosan–Alginate Nanocontainers Loaded with ZnO and Caffeine for Corrosion Protection of Mild Steel
by: Kamelia Kamburova, et al.
Published: (2025-01-01)

<i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing
by: Ioana Bâldea, et al.
Published: (2025-01-01)

Color, Structure, and Thermal Stability of Alginate Films with Raspberry and/or Black Currant Seed Oils
by: Jolanta Kowalonek, et al.
Published: (2025-01-01)

Development of Alginate-Chitosan Bioactive Films Containing Essential Oils for Use in Food Packaging
by: Carla Guzmán-Pincheira, et al.
Published: (2025-01-01)

Effects of foliar applications of γ-polyglutamic acid and alginic acid on the quality and antioxidant activity of Marselan grapes and wines
by: Huawei Chen, et al.
Published: (2025-01-01)

Encapsulation of Lactiplantibacillus plantarum and Beetroot Extract with Alginate and Effect of Capsules on Rheological Properties and Stability of an Oil-in-Water Emulsion Model Food
by: Minerva Bautista Villarreal, et al.
Published: (2023-08-01)

Comparing multivalent cross-linked Sodium Alginate/ Montmorillonite beads containing Curcumin or Cayenne Pepper as drug carriers and their antimicrobial resistance
by: Shionainn Traynor, et al.
Published: (2024-12-01)

Optimizations of Placenta Extracellular Matrix‐Loaded Silk Fibroin/Alginate 3D‐Printed Scaffolds Structurally and Functionally for Bone Tissue Engineering
by: Zahra Bashiri, et al.
Published: (2025-01-01)

Alginate-based encapsulation of porcine placenta extract: Preparation, enteric sustained release, biological activities, and stability
by: Anukul Taweechaipaisankul, et al.
Published: (2025-06-01)

Advantages of alginate and PPI combination in relief of heartburn and regurgitation during the first days of treatment of gastroesophageal reflux disease
by: D. S. Bordin, et al.
Published: (2015-10-01)

Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering
by: Afsaneh Jahani, et al.
Published: (2025-03-01)

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice
by: Jie Li, et al.
Published: (2023-11-01)

Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats
by: Jing Li, et al.
Published: (2025-01-01)

A new paradigm in PhD education: mapping and integrating psychosocial competencies to the PhD curriculum
by: Diane A. Safer, et al.
Published: (2025-01-01)