Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation
Abstract Lysyl-tRNA synthetase 1 (KARS1), an aminoacyl-tRNA synthetase, was recently identified as a secreted pro-inflammatory agent. However, the vascular secretion and functions of KARS1 have not been characterized. This study investigated the secretion mechanisms of KARS1 and explored its functio...
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| Main Authors: | Kangmin Yun, Youngsik Seo, Yerim Oh, Sunghyen Kim, Hye Sun Maeng, Jin Gu Cho, Young Bae Son, Dong Ju Son, Kihwan Kwon, Sunghoon Kim, Hanjoong Jo, Heonyong Park |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-96046-y |
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