Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools
Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. It is not only due to a limit...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/4392017 |
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| author | Magdalena Kuzma-Kozakiewicz Andrzej Marchel Anna Kaminska Malgorzata Gawel Jan Sznajder Anna Figiel-Dabrowska Arkadiusz Nowak Edyta Maj Natalia Ewa Krzesniak Bartlomiej H. Noszczyk Krystyna Domanska-Janik Anna Sarnowska |
| author_facet | Magdalena Kuzma-Kozakiewicz Andrzej Marchel Anna Kaminska Malgorzata Gawel Jan Sznajder Anna Figiel-Dabrowska Arkadiusz Nowak Edyta Maj Natalia Ewa Krzesniak Bartlomiej H. Noszczyk Krystyna Domanska-Janik Anna Sarnowska |
| author_sort | Magdalena Kuzma-Kozakiewicz |
| collection | DOAJ |
| description | Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes. Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts. They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set. Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality of transplanted cells and to correlate ADRC properties with clinical outcome. |
| format | Article |
| id | doaj-art-aed6bc14a00842b0acacf56e1c57f664 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-aed6bc14a00842b0acacf56e1c57f6642025-02-03T01:22:14ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/43920174392017Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring ToolsMagdalena Kuzma-Kozakiewicz0Andrzej Marchel1Anna Kaminska2Malgorzata Gawel3Jan Sznajder4Anna Figiel-Dabrowska5Arkadiusz Nowak6Edyta Maj7Natalia Ewa Krzesniak8Bartlomiej H. Noszczyk9Krystyna Domanska-Janik10Anna Sarnowska11Department of Neurology, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, PolandDepartment of Neurosurgery, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, PolandDepartment of Neurology, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, PolandDepartment of Neurology, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, PolandDepartment of Rehabilitation, Józef Piłsudski University of Physical Education in Warsaw, Marymoncka Str. 34, 00-968 Warsaw, PolandMossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02-106 Warsaw, PolandDepartment of Neurosurgery, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, Poland2nd Department of Clinical Radiology, Medical University of Warsaw, Zwirki i Wigury 61 Str, 02-091 Warsaw, PolandDepartment of Plastic and Reconstructive Surgery, Centre of Postgraduate Medical Education, Prof. W. Orlowski Memorial Hospital, Czerniakowska 231, 00-416 Warsaw, PolandDepartment of Plastic and Reconstructive Surgery, Centre of Postgraduate Medical Education, Prof. W. Orlowski Memorial Hospital, Czerniakowska 231, 00-416 Warsaw, PolandMossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02-106 Warsaw, PolandMossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02-106 Warsaw, PolandStem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes. Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts. They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set. Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality of transplanted cells and to correlate ADRC properties with clinical outcome.http://dx.doi.org/10.1155/2018/4392017 |
| spellingShingle | Magdalena Kuzma-Kozakiewicz Andrzej Marchel Anna Kaminska Malgorzata Gawel Jan Sznajder Anna Figiel-Dabrowska Arkadiusz Nowak Edyta Maj Natalia Ewa Krzesniak Bartlomiej H. Noszczyk Krystyna Domanska-Janik Anna Sarnowska Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools Stem Cells International |
| title | Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools |
| title_full | Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools |
| title_fullStr | Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools |
| title_full_unstemmed | Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools |
| title_short | Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools |
| title_sort | intraspinal transplantation of the adipose tissue derived regenerative cells in amyotrophic lateral sclerosis in accordance with the current experts recommendations choosing optimal monitoring tools |
| url | http://dx.doi.org/10.1155/2018/4392017 |
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