Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/352315 |
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| author | Andrew R. Pepper Boris Gala-Lopez Oliver Ziff A. M. James Shapiro |
| author_facet | Andrew R. Pepper Boris Gala-Lopez Oliver Ziff A. M. James Shapiro |
| author_sort | Andrew R. Pepper |
| collection | DOAJ |
| description | Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings. |
| format | Article |
| id | doaj-art-aecbb670243a48e987966b1019a3a123 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-aecbb670243a48e987966b1019a3a1232025-02-03T01:02:40ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/352315352315Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation SiteAndrew R. Pepper0Boris Gala-Lopez1Oliver Ziff2A. M. James Shapiro3Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, T6G 2C8, CanadaClinical Islet Transplant Program, University of Alberta, Edmonton, AB, T6G 2C8, CanadaDepartment of Surgery, University of Alberta, Edmonton, AB, T6G 2C8, CanadaClinical Islet Transplant Program, University of Alberta, Edmonton, AB, T6G 2C8, CanadaSince the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings.http://dx.doi.org/10.1155/2013/352315 |
| spellingShingle | Andrew R. Pepper Boris Gala-Lopez Oliver Ziff A. M. James Shapiro Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site Clinical and Developmental Immunology |
| title | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
| title_full | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
| title_fullStr | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
| title_full_unstemmed | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
| title_short | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
| title_sort | revascularization of transplanted pancreatic islets and role of the transplantation site |
| url | http://dx.doi.org/10.1155/2013/352315 |
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