The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes
Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Type 2 diabetes (T2DM) is a condition typically cau...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/9132052 |
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| author | Basilio Pintaudi Giacoma Di Vieste Matteo Bonomo |
| author_facet | Basilio Pintaudi Giacoma Di Vieste Matteo Bonomo |
| author_sort | Basilio Pintaudi |
| collection | DOAJ |
| description | Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance. There is a lack of evidence of inositol use in T2DM. We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM. This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7.0–10.0%) already treated with glucose-lowering agents. Patients (23.1% males, mean age of 60.8±11.7 years) took for three months a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg) orally twice a day as add-on supplement to their glucose-lowering drugs. Possible occurrence of side effects was investigated. After three months of treatment fasting blood glucose (192.6±60.2 versus 160.9±36.4; p=0.02) and HbA1c levels (8.6±0.9 versus 7.7±0.9; p=0.02) significantly decreased compared to baseline. There was no significant difference in blood pressure, lipid profile, and BMI levels. None of the participants reported side effects. In conclusion, a supplementation with a combination of myo- and d-chiro-inositol is an effective and safe strategy for improving glycemic control in T2DM. |
| format | Article |
| id | doaj-art-aecb6907670b4656ad0aff06ae31e1a1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-aecb6907670b4656ad0aff06ae31e1a12025-02-03T01:24:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/91320529132052The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 DiabetesBasilio Pintaudi0Giacoma Di Vieste1Matteo Bonomo2Diabetes Unit, Niguarda Cà Granda Hospital, 20162 Milan, ItalyDiabetes Unit, Cantù Hospital, 20081 Abbiategrasso, ItalyDiabetes Unit, Niguarda Cà Granda Hospital, 20162 Milan, ItalyInositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance. There is a lack of evidence of inositol use in T2DM. We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM. This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7.0–10.0%) already treated with glucose-lowering agents. Patients (23.1% males, mean age of 60.8±11.7 years) took for three months a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg) orally twice a day as add-on supplement to their glucose-lowering drugs. Possible occurrence of side effects was investigated. After three months of treatment fasting blood glucose (192.6±60.2 versus 160.9±36.4; p=0.02) and HbA1c levels (8.6±0.9 versus 7.7±0.9; p=0.02) significantly decreased compared to baseline. There was no significant difference in blood pressure, lipid profile, and BMI levels. None of the participants reported side effects. In conclusion, a supplementation with a combination of myo- and d-chiro-inositol is an effective and safe strategy for improving glycemic control in T2DM.http://dx.doi.org/10.1155/2016/9132052 |
| spellingShingle | Basilio Pintaudi Giacoma Di Vieste Matteo Bonomo The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes International Journal of Endocrinology |
| title | The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes |
| title_full | The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes |
| title_fullStr | The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes |
| title_full_unstemmed | The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes |
| title_short | The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes |
| title_sort | effectiveness of myo inositol and d chiro inositol treatment in type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/9132052 |
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