TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism

TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism

Summary: Tlx3, a master regulator of the fate specification of excitatory neurons, is primarily known to function in post-mitotic cells. Although we have previously identified TLX3 expression in the proliferating granule neuron progenitors (GNPs) of cerebellum, its primary role is unknown. Here, we...

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Main Authors: Surendran Parvathy, Budhaditya Basu, Suresh Surya, Rahul Jose, Vadakkath Meera, Paul Ann Riya, Nair Pradeep Jyothi, Rajendran Sanalkumar, Viviane Praz, Nicolò Riggi, Biju Surendran Nair, Kamalesh K. Gulia, Mukesh Kumar, Balachandran Krishnamma Binukumar, Jackson James
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Neuroscience
Molecular Neuroscience
Cellular Neuroscience
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224024854
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