SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM
Purpose: to study serum adipokine levels and AdipoR1, AdipoR2 and sOb-R expressions with respect to clinical-morphological parameters and the evidence of metaboloc syndrome (MS) in patients with stage I–III colon cancer.Materials and methods. The study included 31 colon cancer patients having metabo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/269 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849253187077275648 |
|---|---|
| author | N. V. Yunusova I. V. Kondakova S. G. Afanasyev О. V. Shatokhina N. P. Kovalyeva А. Е. Frolova Е. S. Kolegova |
| author_facet | N. V. Yunusova I. V. Kondakova S. G. Afanasyev О. V. Shatokhina N. P. Kovalyeva А. Е. Frolova Е. S. Kolegova |
| author_sort | N. V. Yunusova |
| collection | DOAJ |
| description | Purpose: to study serum adipokine levels and AdipoR1, AdipoR2 and sOb-R expressions with respect to clinical-morphological parameters and the evidence of metaboloc syndrome (MS) in patients with stage I–III colon cancer.Materials and methods. The study included 31 colon cancer patients having metabolic syndrome and patients having no metabolic syndrome. Serum levels of leptin, adiponektin, AdipoR1, AdipoR2 and soluble form of the leptin receptor was assessed by ELISA.Results and conclusion. The incidence of MS in colon cancer patients was 71 %. The relationship between the serum leptin level and gender and disease stage was revealed. The tendency toward increase in the leptin level in patients with MS was shown. The Ob-R level was higher in patients having no MS. The levels of AdipoR1 and AdipoR2 were significantly higher in female colon cancer patients. Adiponectin receptors tended to increase in colon cancer patients with MS. |
| format | Article |
| id | doaj-art-aec4cd08b30f4663b8f72405751997c5 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-aec4cd08b30f4663b8f72405751997c52025-08-20T03:56:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01052428269SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROMN. V. Yunusova0I. V. Kondakova1S. G. Afanasyev2О. V. Shatokhina3N. P. Kovalyeva4А. Е. Frolova5Е. S. Kolegova6Tomsk Cancer Research Institute Siberian State Medical University, TomskTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research InstituteSiberian State Medical University, TomskSiberian State Medical University, TomskPurpose: to study serum adipokine levels and AdipoR1, AdipoR2 and sOb-R expressions with respect to clinical-morphological parameters and the evidence of metaboloc syndrome (MS) in patients with stage I–III colon cancer.Materials and methods. The study included 31 colon cancer patients having metabolic syndrome and patients having no metabolic syndrome. Serum levels of leptin, adiponektin, AdipoR1, AdipoR2 and soluble form of the leptin receptor was assessed by ELISA.Results and conclusion. The incidence of MS in colon cancer patients was 71 %. The relationship between the serum leptin level and gender and disease stage was revealed. The tendency toward increase in the leptin level in patients with MS was shown. The Ob-R level was higher in patients having no MS. The levels of AdipoR1 and AdipoR2 were significantly higher in female colon cancer patients. Adiponectin receptors tended to increase in colon cancer patients with MS.https://www.siboncoj.ru/jour/article/view/269serum adipokinesadipokine receptorscolon cancermetabolic syndrome |
| spellingShingle | N. V. Yunusova I. V. Kondakova S. G. Afanasyev О. V. Shatokhina N. P. Kovalyeva А. Е. Frolova Е. S. Kolegova SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM Сибирский онкологический журнал serum adipokines adipokine receptors colon cancer metabolic syndrome |
| title | SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM |
| title_full | SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM |
| title_fullStr | SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM |
| title_full_unstemmed | SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM |
| title_short | SERUM ADIPOKINES AND ADIPOKINE RECEPTORS IN COLON CANCER PATIENTS WITH METABOLOC SYNDROM |
| title_sort | serum adipokines and adipokine receptors in colon cancer patients with metaboloc syndrom |
| topic | serum adipokines adipokine receptors colon cancer metabolic syndrome |
| url | https://www.siboncoj.ru/jour/article/view/269 |
| work_keys_str_mv | AT nvyunusova serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT ivkondakova serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT sgafanasyev serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT ovshatokhina serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT npkovalyeva serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT aefrolova serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom AT eskolegova serumadipokinesandadipokinereceptorsincoloncancerpatientswithmetabolocsyndrom |