Sustainability-based comparative stability of oxaliplatin plus leucovorin and 5-fluorouracil in infusion bags with application to plasma and colonic media samples

Sustainability-based comparative stability of oxaliplatin plus leucovorin and 5-fluorouracil in infusion bags with application to plasma and colonic media samples

Abstract FOLFOX is widely used in the treatment of colon cancer. The combination of oxaliplatin (OXA), 5-fluorouracil (5-FU), and leucovorin (LV) is administrated according to strict protocols. Based on incompatibility studies, LV and OXA are supplied concurrently via intravenous infusion, followed...

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Bibliographic Details
Main Authors: Hadir M. Maher, Salma Mahmoud Mohamed, Ekram M. Hassan, Amira Fawzy El-Yazbi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
HPLC-DAD
FOLFOX
Stability
Infusion bags
Normal saline
5% dextrose
Online Access:https://doi.org/10.1038/s41598-025-02079-8
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