Drug-induced bone disorders: A systematic review

Drug-induced bone disorders are a group of disorders characterized by osteomalacia or osteoporosis, with the common denominator being the iatrogenic nature of the disease. Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclast...

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Main Authors: Anshita Aggarwal, Meha Sharma, Indira Maisnam, Soumitra Ghosh, Sameer Aggarwal, Saptarshi Bhattacharya, Deep Dutta
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:Indian Journal of Rheumatology
Subjects:
Online Access:http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=44;epage=51;aulast=Aggarwal
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author Anshita Aggarwal
Meha Sharma
Indira Maisnam
Soumitra Ghosh
Sameer Aggarwal
Saptarshi Bhattacharya
Deep Dutta
author_facet Anshita Aggarwal
Meha Sharma
Indira Maisnam
Soumitra Ghosh
Sameer Aggarwal
Saptarshi Bhattacharya
Deep Dutta
author_sort Anshita Aggarwal
collection DOAJ
description Drug-induced bone disorders are a group of disorders characterized by osteomalacia or osteoporosis, with the common denominator being the iatrogenic nature of the disease. Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclastic activity) or indirectly by interfering with Vitamin D metabolism, Vitamin D/calcium absorption, and excess calcium loss or due to altered hormone states which promote bone loss (hypogonadism, hyperthyroidism, somatostatin excess states, insulin deficiency, increased systemic inflammation, and oxidative stress). References for this review were identified through searches of PubMed, Medline, and Embase for articles published until July 2019 using the terms “drug induced bone disorders” (MeSH Terms) AND “osteoporosis” (All Fields) OR “osteomalacia” (All Fields). Anti-epileptics, proton pump inhibitors, glucocorticoids, immunosuppressants (calcineurin inhibitors), anticoagulants, glitazones, SGLT2 inhibitors, somatostatin analogs, anticancer medications, and protein kinase inhibitors are some of the commonly used medications associated with bone mineral loss. An increased awareness, minimizing the use of these medications in patients at increased risk of fractures, keeping dosage and duration of therapy to the lowest, ensuring Vitamin D and calcium adequacy either through diet or supplements, and prophylactic use of bisphosphonates (where indicated) can play a major role in preventing morbidity associated with drug-induced bone disorders.
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spelling doaj-art-aea85b1aa2b6425bbac6b79fa63a1f642025-02-03T00:25:14ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012019-01-01145445110.4103/0973-3698.272152Drug-induced bone disorders: A systematic reviewAnshita AggarwalMeha SharmaIndira MaisnamSoumitra GhoshSameer AggarwalSaptarshi BhattacharyaDeep DuttaDrug-induced bone disorders are a group of disorders characterized by osteomalacia or osteoporosis, with the common denominator being the iatrogenic nature of the disease. Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclastic activity) or indirectly by interfering with Vitamin D metabolism, Vitamin D/calcium absorption, and excess calcium loss or due to altered hormone states which promote bone loss (hypogonadism, hyperthyroidism, somatostatin excess states, insulin deficiency, increased systemic inflammation, and oxidative stress). References for this review were identified through searches of PubMed, Medline, and Embase for articles published until July 2019 using the terms “drug induced bone disorders” (MeSH Terms) AND “osteoporosis” (All Fields) OR “osteomalacia” (All Fields). Anti-epileptics, proton pump inhibitors, glucocorticoids, immunosuppressants (calcineurin inhibitors), anticoagulants, glitazones, SGLT2 inhibitors, somatostatin analogs, anticancer medications, and protein kinase inhibitors are some of the commonly used medications associated with bone mineral loss. An increased awareness, minimizing the use of these medications in patients at increased risk of fractures, keeping dosage and duration of therapy to the lowest, ensuring Vitamin D and calcium adequacy either through diet or supplements, and prophylactic use of bisphosphonates (where indicated) can play a major role in preventing morbidity associated with drug-induced bone disorders.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=44;epage=51;aulast=Aggarwaldrug-induced osteoporosisdrug-induced osteomalaciametabolic bone diseasevitamin d
spellingShingle Anshita Aggarwal
Meha Sharma
Indira Maisnam
Soumitra Ghosh
Sameer Aggarwal
Saptarshi Bhattacharya
Deep Dutta
Drug-induced bone disorders: A systematic review
Indian Journal of Rheumatology
drug-induced osteoporosis
drug-induced osteomalacia
metabolic bone disease
vitamin d
title Drug-induced bone disorders: A systematic review
title_full Drug-induced bone disorders: A systematic review
title_fullStr Drug-induced bone disorders: A systematic review
title_full_unstemmed Drug-induced bone disorders: A systematic review
title_short Drug-induced bone disorders: A systematic review
title_sort drug induced bone disorders a systematic review
topic drug-induced osteoporosis
drug-induced osteomalacia
metabolic bone disease
vitamin d
url http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=44;epage=51;aulast=Aggarwal
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AT soumitraghosh druginducedbonedisordersasystematicreview
AT sameeraggarwal druginducedbonedisordersasystematicreview
AT saptarshibhattacharya druginducedbonedisordersasystematicreview
AT deepdutta druginducedbonedisordersasystematicreview