Neutrophils, NETs and multiple sclerosis: a mini review
Multiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487814/full |
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| author | Moyuan Quan Moyuan Quan Moyuan Quan Huining Zhang Huining Zhang Huining Zhang Xiaohong Deng Huijia Liu Yanqiu Xu Xiujuan Song Xiujuan Song Xiujuan Song |
| author_facet | Moyuan Quan Moyuan Quan Moyuan Quan Huining Zhang Huining Zhang Huining Zhang Xiaohong Deng Huijia Liu Yanqiu Xu Xiujuan Song Xiujuan Song Xiujuan Song |
| author_sort | Moyuan Quan |
| collection | DOAJ |
| description | Multiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. Neutrophils play multiple roles in mediating the pathogenesis of autoimmune diseases, and numerous studies suggest that neutrophils might have a crucial role through neutrophil extracellular trap (NET) formation. Studies on NETs in MS are still in their infancy. In this review, we discuss the clinical perspective on the linkage between neutrophils and MS or EAE, as well as the role of NETs in the pathogenesis of MS/EAE. Further, we analyze the potential mechanisms by which NETs contribute to MS, the protective effects of NETs in MS, and their value as targets for disease intervention. NET formation and/or clearance as a therapeutic approach for MS still requires research in greater depth. |
| format | Article |
| id | doaj-art-aea787ca346343edb9a37b674b490f6c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-aea787ca346343edb9a37b674b490f6c2025-01-28T05:10:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14878141487814Neutrophils, NETs and multiple sclerosis: a mini reviewMoyuan Quan0Moyuan Quan1Moyuan Quan2Huining Zhang3Huining Zhang4Huining Zhang5Xiaohong Deng6Huijia Liu7Yanqiu Xu8Xiujuan Song9Xiujuan Song10Xiujuan Song11Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaKey Laboratory of Neurology of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaKey Laboratory of Neurology of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Rehabilitation Medicine, Beijing Zhongguancun Hospital, Beijing, ChinaDepartment of Internal Medicine, The Military Special Care Hospital of Shijiazhuang, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaKey Laboratory of Neurology of Hebei Province, Shijiazhuang, Hebei, ChinaMultiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. Neutrophils play multiple roles in mediating the pathogenesis of autoimmune diseases, and numerous studies suggest that neutrophils might have a crucial role through neutrophil extracellular trap (NET) formation. Studies on NETs in MS are still in their infancy. In this review, we discuss the clinical perspective on the linkage between neutrophils and MS or EAE, as well as the role of NETs in the pathogenesis of MS/EAE. Further, we analyze the potential mechanisms by which NETs contribute to MS, the protective effects of NETs in MS, and their value as targets for disease intervention. NET formation and/or clearance as a therapeutic approach for MS still requires research in greater depth.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487814/fullmultiple sclerosisexperimental autoimmune encephalomyelitisneutrophilsneutrophil extracellular trapstherapeutic target |
| spellingShingle | Moyuan Quan Moyuan Quan Moyuan Quan Huining Zhang Huining Zhang Huining Zhang Xiaohong Deng Huijia Liu Yanqiu Xu Xiujuan Song Xiujuan Song Xiujuan Song Neutrophils, NETs and multiple sclerosis: a mini review Frontiers in Immunology multiple sclerosis experimental autoimmune encephalomyelitis neutrophils neutrophil extracellular traps therapeutic target |
| title | Neutrophils, NETs and multiple sclerosis: a mini review |
| title_full | Neutrophils, NETs and multiple sclerosis: a mini review |
| title_fullStr | Neutrophils, NETs and multiple sclerosis: a mini review |
| title_full_unstemmed | Neutrophils, NETs and multiple sclerosis: a mini review |
| title_short | Neutrophils, NETs and multiple sclerosis: a mini review |
| title_sort | neutrophils nets and multiple sclerosis a mini review |
| topic | multiple sclerosis experimental autoimmune encephalomyelitis neutrophils neutrophil extracellular traps therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487814/full |
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