Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy
This paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients. Antioxidant enzymes, malondialdehyde(MDA), urea, creatinine, and glo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2012/767501 |
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| author | M. A. Emokpae P. O. Uadia |
| author_facet | M. A. Emokpae P. O. Uadia |
| author_sort | M. A. Emokpae |
| collection | DOAJ |
| description | This paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients. Antioxidant enzymes, malondialdehyde(MDA), urea, creatinine, and glomerular filtration rate were evaluated in 110 confirmed sickle cell disease patients: 65 males in steady state, aged 21.1±6.0 years, 30 males with macroalbuminuria, aged 24.5±7.0, years and 15 with chronic kidney disease (CKD), aged 31.8±2.0 years. The mean activity levels of glutathione peroxidase (GPx), superoxide dismutase (Cu/ZnSOD), and catalase (CAT) were significantly lower (P<0.001) in SCD with macroalbuminuria and CKD while MDA was higher (P<0.001) in SCD with macroalbuminuria and CKD compared with controls. There was negative correlation between GPx (P<0.001), Cu/ZnSOD (P<0.02), and Atherogenic index of plasma in SCD with CKD, while MDA shows a positive correlation (P<0.001) with AIP in SCD with CKD. There was however no correlation between CAT and AIP. Decreased activity levels of antioxidant enzymes and low HDL-cholesterol concentration were confirmed in adult SCD with CKD in Nigerians. The increase oxidative stress and high atherogenic index in CKD may accelerate the process of cardiovascular complications in adult SCD patients. Atherogenic index of plasma was negatively correlated with antioxidant enzymes and positively with MDA. |
| format | Article |
| id | doaj-art-ae78cce7015340f1b198ff99666daa8c |
| institution | Kabale University |
| issn | 2090-1267 2090-1275 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-ae78cce7015340f1b198ff99666daa8c2025-02-03T05:52:41ZengWileyAnemia2090-12672090-12752012-01-01201210.1155/2012/767501767501Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell NephropathyM. A. Emokpae0P. O. Uadia1Department of Chemical Pathology, Aminu Kano Teaching Hospital, Kano 700001, NigeriaDepartment of Biochemistry, University of Benin, Benin City 300001, NigeriaThis paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients. Antioxidant enzymes, malondialdehyde(MDA), urea, creatinine, and glomerular filtration rate were evaluated in 110 confirmed sickle cell disease patients: 65 males in steady state, aged 21.1±6.0 years, 30 males with macroalbuminuria, aged 24.5±7.0, years and 15 with chronic kidney disease (CKD), aged 31.8±2.0 years. The mean activity levels of glutathione peroxidase (GPx), superoxide dismutase (Cu/ZnSOD), and catalase (CAT) were significantly lower (P<0.001) in SCD with macroalbuminuria and CKD while MDA was higher (P<0.001) in SCD with macroalbuminuria and CKD compared with controls. There was negative correlation between GPx (P<0.001), Cu/ZnSOD (P<0.02), and Atherogenic index of plasma in SCD with CKD, while MDA shows a positive correlation (P<0.001) with AIP in SCD with CKD. There was however no correlation between CAT and AIP. Decreased activity levels of antioxidant enzymes and low HDL-cholesterol concentration were confirmed in adult SCD with CKD in Nigerians. The increase oxidative stress and high atherogenic index in CKD may accelerate the process of cardiovascular complications in adult SCD patients. Atherogenic index of plasma was negatively correlated with antioxidant enzymes and positively with MDA.http://dx.doi.org/10.1155/2012/767501 |
| spellingShingle | M. A. Emokpae P. O. Uadia Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy Anemia |
| title | Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy |
| title_full | Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy |
| title_fullStr | Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy |
| title_full_unstemmed | Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy |
| title_short | Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy |
| title_sort | association of oxidative stress markers with atherogenic index of plasma in adult sickle cell nephropathy |
| url | http://dx.doi.org/10.1155/2012/767501 |
| work_keys_str_mv | AT maemokpae associationofoxidativestressmarkerswithatherogenicindexofplasmainadultsicklecellnephropathy AT pouadia associationofoxidativestressmarkerswithatherogenicindexofplasmainadultsicklecellnephropathy |