Cardamonin inhibits the growth and stemness of osteosarcoma stem cells by inducing autophagy and inhibiting the Wnt/β-catenin signaling pathway

Cardamonin inhibits the growth and stemness of osteosarcoma stem cells by inducing autophagy and inhibiting the Wnt/β-catenin signaling pathway

Abstract Cardamonin (CDN) has been shown to have promising anticancer effects against osteosarcoma (OS). Nevertheless, the molecular processes of it are still not well understood. Our investigation revealed that CDN has significant cytotoxic effects and diminishes cell viability in OS. The self-rene...

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Bibliographic Details
Main Authors: Lulu Zhang, Yu Jin, Qiannan Ding, Yulei Li, Lixia Yang, Mengyun Li, Zuo Lv, Kaifang Wang, Maowei Yang, Haixin Zhang, Xiucheng Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Osteosarcoma
Cardamom
Cancer stem cell
Autophagy
Wnt/β-catenin signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-14209-3
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