Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?
Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of ove...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/759139 |
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| author | Cristiano A. Köhler André F. Carvalho Gilberto S. Alves Roger S. McIntyre Thomas N. Hyphantis Martín Cammarota |
| author_facet | Cristiano A. Köhler André F. Carvalho Gilberto S. Alves Roger S. McIntyre Thomas N. Hyphantis Martín Cammarota |
| author_sort | Cristiano A. Köhler |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment. |
| format | Article |
| id | doaj-art-ae704e70f0c341c7b16e9407caf86ace |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ae704e70f0c341c7b16e9407caf86ace2025-02-03T06:42:10ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/759139759139Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?Cristiano A. Köhler0André F. Carvalho1Gilberto S. Alves2Roger S. McIntyre3Thomas N. Hyphantis4Martín Cammarota5Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte (UFRN), 59056-450 Natal, RN, BrazilTranslational Psychiatry Research Group and Department of Clinical Medicine, Federal University of Ceara, 60430-140 Fortaleza, CE, BrazilTranslational Psychiatry Research Group and Department of Clinical Medicine, Federal University of Ceara, 60430-140 Fortaleza, CE, BrazilDepartments of Psychiatry and Pharmacology, University of Toronto, Toronto, ON, M5T 2S8, CanadaDepartment of Psychiatry, University of Ioannina, 45110 Ioannina, GreeceMemory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte (UFRN), 59056-450 Natal, RN, BrazilMajor depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment.http://dx.doi.org/10.1155/2015/759139 |
| spellingShingle | Cristiano A. Köhler André F. Carvalho Gilberto S. Alves Roger S. McIntyre Thomas N. Hyphantis Martín Cammarota Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? Neural Plasticity |
| title | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
| title_full | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
| title_fullStr | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
| title_full_unstemmed | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
| title_short | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
| title_sort | autobiographical memory disturbances in depression a novel therapeutic target |
| url | http://dx.doi.org/10.1155/2015/759139 |
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