Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma
Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of ge...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359890910 |
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| _version_ | 1832563046176784384 |
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| author | V. H. J. van der Velden |
| author_facet | V. H. J. van der Velden |
| author_sort | V. H. J. van der Velden |
| collection | DOAJ |
| description | Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in particular activating protein-1 or nuclear factor-κB. Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules. In contrast, anti-inflammatory mediators often are up-regulated by glucocorticoids. In vivo studies have shown that treatment of asthmatic patients with inhaled glucocorticoids inhibits the bronchial inflammation and simultaneously improves their lung function. In this review, our current knowledge of the mechanism of action of glucocorticoids and their anti-inflammatory potential in asthma is described. Since bronchial epithelial cells may be important targets for glucocorticoid therapy in asthma, the effects of glucocorticoids on epithelial expressed inflammatory genes will be emphasized. |
| format | Article |
| id | doaj-art-ae6ec201ba5d49e781140ebf2f2d9072 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ae6ec201ba5d49e781140ebf2f2d90722025-02-03T01:21:07ZengWileyMediators of Inflammation0962-93511466-18611998-01-017422923710.1080/09629359890910Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthmaV. H. J. van der Velden0Department of Immunology, Erasmus University, PO Box 1738, Rotterdam 3000 DR, The NetherlandsGlucocorticoids are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in particular activating protein-1 or nuclear factor-κB. Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules. In contrast, anti-inflammatory mediators often are up-regulated by glucocorticoids. In vivo studies have shown that treatment of asthmatic patients with inhaled glucocorticoids inhibits the bronchial inflammation and simultaneously improves their lung function. In this review, our current knowledge of the mechanism of action of glucocorticoids and their anti-inflammatory potential in asthma is described. Since bronchial epithelial cells may be important targets for glucocorticoid therapy in asthma, the effects of glucocorticoids on epithelial expressed inflammatory genes will be emphasized.http://dx.doi.org/10.1080/09629359890910GlucocorticoidsAsthmaBronchial epithelial cellsInflammation. |
| spellingShingle | V. H. J. van der Velden Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma Mediators of Inflammation Glucocorticoids Asthma Bronchial epithelial cells Inflammation. |
| title | Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma |
| title_full | Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma |
| title_fullStr | Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma |
| title_full_unstemmed | Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma |
| title_short | Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma |
| title_sort | glucocorticoids mechanisms of action and anti inflammatory potential in asthma |
| topic | Glucocorticoids Asthma Bronchial epithelial cells Inflammation. |
| url | http://dx.doi.org/10.1080/09629359890910 |
| work_keys_str_mv | AT vhjvandervelden glucocorticoidsmechanismsofactionandantiinflammatorypotentialinasthma |