Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck
The survival of patients with a head‐and‐neck squamous cell carcinoma is determined by loco‐regional recurrence and second primary carcinomas. As a complement to histopathology, molecular changes of tumour marginal and tumour distant tissue may confirm curative surgical tumour extirpation. We tested...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2002/452527 |
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| author | Eva‐Maria Fabricius Ulrike Gurr Gustav‐Paul Wildner |
| author_facet | Eva‐Maria Fabricius Ulrike Gurr Gustav‐Paul Wildner |
| author_sort | Eva‐Maria Fabricius |
| collection | DOAJ |
| description | The survival of patients with a head‐and‐neck squamous cell carcinoma is determined by loco‐regional recurrence and second primary carcinomas. As a complement to histopathology, molecular changes of tumour marginal and tumour distant tissue may confirm curative surgical tumour extirpation. We tested telomerase activity with PCR‐ELISA kits. 20 tumour margin biopsies were chosen by the surgeon from 20 patients. In addition, 3 tissue samples were taken from each of 20 additional patients, one from the carcinoma centre, the tumour margin and one distant from the tumour. 50% of the carcinoma centres were telomerase‐positive. Thirteen of the 40 tumour margin samples showed increased telomerase levels, and in 3 of these residual carcinoma was histopathologically detected. Six of the 20 tumour distant tissues revealed increased telomerase levels. Telomerase positivity in carcinoma‐free tumour margins correlated with a good prognosis. Confirmation of the results in a larger patient group is needed. |
| format | Article |
| id | doaj-art-ae5a7aa858704bea9f87cf0ddfccc351 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-ae5a7aa858704bea9f87cf0ddfccc3512025-02-03T05:51:59ZengWileyAnalytical Cellular Pathology0921-89121878-36512002-01-01241253910.1155/2002/452527Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-NeckEva‐Maria Fabricius0Ulrike Gurr1Gustav‐Paul Wildner2Clinic for Oral and Maxillofacial Surgery, Campus Virchow Hospital, Charité, Medical Faculty of the Humboldt University of Berlin, GermanyClinic for Oral and Maxillofacial Surgery, Campus Virchow Hospital, Charité, Medical Faculty of the Humboldt University of Berlin, GermanyFormerly Department of Pathology, Robert‐Rössle‐Clinic, Campus Berlin‐Buch, Charité, Medical Faculty of the Humboldt University of Berlin, GermanyThe survival of patients with a head‐and‐neck squamous cell carcinoma is determined by loco‐regional recurrence and second primary carcinomas. As a complement to histopathology, molecular changes of tumour marginal and tumour distant tissue may confirm curative surgical tumour extirpation. We tested telomerase activity with PCR‐ELISA kits. 20 tumour margin biopsies were chosen by the surgeon from 20 patients. In addition, 3 tissue samples were taken from each of 20 additional patients, one from the carcinoma centre, the tumour margin and one distant from the tumour. 50% of the carcinoma centres were telomerase‐positive. Thirteen of the 40 tumour margin samples showed increased telomerase levels, and in 3 of these residual carcinoma was histopathologically detected. Six of the 20 tumour distant tissues revealed increased telomerase levels. Telomerase positivity in carcinoma‐free tumour margins correlated with a good prognosis. Confirmation of the results in a larger patient group is needed.http://dx.doi.org/10.1155/2002/452527 |
| spellingShingle | Eva‐Maria Fabricius Ulrike Gurr Gustav‐Paul Wildner Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck Analytical Cellular Pathology |
| title | Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck |
| title_full | Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck |
| title_fullStr | Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck |
| title_full_unstemmed | Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck |
| title_short | Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck |
| title_sort | telomerase activity levels in the surgical margin and tumour distant tissue of the squamous cell carcinoma of the head and neck |
| url | http://dx.doi.org/10.1155/2002/452527 |
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