Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats
The present study aimed to determine whether neonatal treatment with fentanyl has lasting effects on stressed developing brain. Six-day-old rats were assigned to one of three groups (10 males/group): (1) fentanyl (incision+fentanyl), (2) saline (incision+0.9% saline), and (3) unoperated (unoperated...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/180124 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550300203876352 |
|---|---|
| author | Dora Catré Maria Francelina Lopes António Silvério Cabrita |
| author_facet | Dora Catré Maria Francelina Lopes António Silvério Cabrita |
| author_sort | Dora Catré |
| collection | DOAJ |
| description | The present study aimed to determine whether neonatal treatment with fentanyl has lasting effects on stressed developing brain. Six-day-old rats were assigned to one of three groups (10 males/group): (1) fentanyl (incision+fentanyl), (2) saline (incision+0.9% saline), and (3) unoperated (unoperated sham). Pups with a plantar paw incision received repetitive subcutaneous injections of fentanyl or vehicle through postnatal days (PNDs) 6 to 8. A nonoperated sham group served as nonstressed control. Studies included assessment of development from PND 6 to PND 21 (growth indices and behavioral testing). Fentanyl administered twice daily for three days after surgical incision had no impact on early growth and development, as measured on PND 9, but showed a lasting impact on later growth, enhanced behavioral development, and lower anxiety, as measured through PNDs 10–21. While this does not completely support a benefit from such treatment, our findings may contribute to support the neonatal use of fentanyl, when indicated, even in premature newborns. |
| format | Article |
| id | doaj-art-ae4dee6e3bea49db84070b4326d8a02a |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-ae4dee6e3bea49db84070b4326d8a02a2025-02-03T06:07:11ZengWileyAnesthesiology Research and Practice1687-69621687-69702012-01-01201210.1155/2012/180124180124Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling RatsDora Catré0Maria Francelina Lopes1António Silvério Cabrita2Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalFaculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalFaculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalThe present study aimed to determine whether neonatal treatment with fentanyl has lasting effects on stressed developing brain. Six-day-old rats were assigned to one of three groups (10 males/group): (1) fentanyl (incision+fentanyl), (2) saline (incision+0.9% saline), and (3) unoperated (unoperated sham). Pups with a plantar paw incision received repetitive subcutaneous injections of fentanyl or vehicle through postnatal days (PNDs) 6 to 8. A nonoperated sham group served as nonstressed control. Studies included assessment of development from PND 6 to PND 21 (growth indices and behavioral testing). Fentanyl administered twice daily for three days after surgical incision had no impact on early growth and development, as measured on PND 9, but showed a lasting impact on later growth, enhanced behavioral development, and lower anxiety, as measured through PNDs 10–21. While this does not completely support a benefit from such treatment, our findings may contribute to support the neonatal use of fentanyl, when indicated, even in premature newborns.http://dx.doi.org/10.1155/2012/180124 |
| spellingShingle | Dora Catré Maria Francelina Lopes António Silvério Cabrita Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats Anesthesiology Research and Practice |
| title | Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats |
| title_full | Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats |
| title_fullStr | Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats |
| title_full_unstemmed | Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats |
| title_short | Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats |
| title_sort | lasting developmental effects of neonatal fentanyl exposure in preweanling rats |
| url | http://dx.doi.org/10.1155/2012/180124 |
| work_keys_str_mv | AT doracatre lastingdevelopmentaleffectsofneonatalfentanylexposureinpreweanlingrats AT mariafrancelinalopes lastingdevelopmentaleffectsofneonatalfentanylexposureinpreweanlingrats AT antoniosilveriocabrita lastingdevelopmentaleffectsofneonatalfentanylexposureinpreweanlingrats |