Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics
The objective: to trace changes in endotoxicosis in the brain during the postresuscitation period.Subjects and Methods. Clinical death was modeled on rats by 6.5-minute asphyxia and resuscitation.The animals were divided into groups corresponding to the timing of brain sampling (from 30 minutes to 2...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2022-12-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/737 |
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| author | P. P. Zolin |
| author_facet | P. P. Zolin |
| author_sort | P. P. Zolin |
| collection | DOAJ |
| description | The objective: to trace changes in endotoxicosis in the brain during the postresuscitation period.Subjects and Methods. Clinical death was modeled on rats by 6.5-minute asphyxia and resuscitation.The animals were divided into groups corresponding to the timing of brain sampling (from 30 minutes to 21 days) after resuscitation. The content of low and median molecular weight substances (LMMWS) was determined in perchloric acid extracts of the brain.Results. It was found that 30 minutes after resuscitation the content of LMMWS in the brain of rats increases statistically significantly compared to the "control" group, and after 90 minutes returns to the control level. Then, 6 hours – 21 days after resuscitation a paradoxical decrease in the content of LMMWS below the control level occurs.Conclusion. The decrease in the level of endotoxicosis after asphyxia and resuscitation explains not by their “healing” effect, but by the death of rats with the highest LMMWS values, which leads to a decrease in the average LMMWS value in groups of resuscitated animals. |
| format | Article |
| id | doaj-art-ae4b3d1056c74bcea00a2b578adeb221 |
| institution | DOAJ |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-ae4b3d1056c74bcea00a2b578adeb2212025-08-20T03:18:55ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532022-12-01196556110.21292/2078-5658-2022-19-6-55-61562Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical StatisticsP. P. Zolin0Omsk State Medical UniversityThe objective: to trace changes in endotoxicosis in the brain during the postresuscitation period.Subjects and Methods. Clinical death was modeled on rats by 6.5-minute asphyxia and resuscitation.The animals were divided into groups corresponding to the timing of brain sampling (from 30 minutes to 21 days) after resuscitation. The content of low and median molecular weight substances (LMMWS) was determined in perchloric acid extracts of the brain.Results. It was found that 30 minutes after resuscitation the content of LMMWS in the brain of rats increases statistically significantly compared to the "control" group, and after 90 minutes returns to the control level. Then, 6 hours – 21 days after resuscitation a paradoxical decrease in the content of LMMWS below the control level occurs.Conclusion. The decrease in the level of endotoxicosis after asphyxia and resuscitation explains not by their “healing” effect, but by the death of rats with the highest LMMWS values, which leads to a decrease in the average LMMWS value in groups of resuscitated animals.https://www.vair-journal.com/jour/article/view/737postresuscitation periodbrainendogenous intoxicationlow and median molecular weight substancesnon-random elisionsrats |
| spellingShingle | P. P. Zolin Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics Вестник анестезиологии и реаниматологии postresuscitation period brain endogenous intoxication low and median molecular weight substances non-random elisions rats |
| title | Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics |
| title_full | Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics |
| title_fullStr | Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics |
| title_full_unstemmed | Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics |
| title_short | Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics |
| title_sort | do clinical death and resuscitation make an organism healthier paradox in medical statistics |
| topic | postresuscitation period brain endogenous intoxication low and median molecular weight substances non-random elisions rats |
| url | https://www.vair-journal.com/jour/article/view/737 |
| work_keys_str_mv | AT ppzolin doclinicaldeathandresuscitationmakeanorganismhealthierparadoxinmedicalstatistics |