Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health
Bisphenol A (BPA) and alkylphenols (APs) are well-known endocrine disrupting chemicals (EDCs) which may threat the next generations' health. We performed biomonitoring of these phenols in colostrums to assess risk of the phenols in breast-fed neonates. Study subjects were the lactating mothers...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/282381 |
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| author | B. Yi C. Kim M. Park Y. Han J. Y. Park M. Yang |
| author_facet | B. Yi C. Kim M. Park Y. Han J. Y. Park M. Yang |
| author_sort | B. Yi |
| collection | DOAJ |
| description | Bisphenol A (BPA) and alkylphenols (APs) are well-known endocrine disrupting chemicals (EDCs) which may threat the next generations' health. We performed biomonitoring of these phenols in colostrums to assess risk of the phenols in breast-fed neonates. Study subjects were the lactating mothers who delivered babies within 2 weeks (N=325; 30.67 ± 3.45 years) and their neonates (N=326; embryonic period, 39.1 ± 1.5 weeks). BPA, nonylphenol (NP), and octylphenol (OP) in colostrums were quantified with LC/MS/MS. Information for environmental exposure sources of the phenols was obtained by questionnaires. As results, median level of BPA in colostrums was 7.8 ng/mL, while most NP or OP was not detected. Regarding health risks of phenols, levels of total NP in colostrums were elevated among sick mothers with toxemia, thyroid disorders, gastritis, and so forth than health mothers (3.51 ± 4.98 versus 2.04 ± 3.71 ng/mL, P=0.02). Dairy products intake and detergents use were positively correlated with total BPA levels (Ps<0.05). In conclusion, we estimate most neonates who are exposed to BPA rather than NP or OP via colostrums and recommend continuous biomonitoring of the phenols to clarify their suspected health risk on neonates and pregnant or gestation mothers. |
| format | Article |
| id | doaj-art-ae48dfcd1c1e438d93d8cdac7cc38b20 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ae48dfcd1c1e438d93d8cdac7cc38b202025-02-03T07:24:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/282381282381Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant HealthB. Yi0C. Kim1M. Park2Y. Han3J. Y. Park4M. Yang5Research Center for Cell Fate Control, Sookmyung Women’s University College of Pharmacy, Seoul 140-742, Republic of KoreaKorea Testing & Research Institute, Gyeonggido 415-871, Republic of KoreaInje University Sanggye Paik Hospital, Seoul 139-707, Republic of KoreaMart Pediatric Clinic, Gyeonggido 456-824, Republic of KoreaDivision of Cancer Prevention and Controls, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USAResearch Center for Cell Fate Control, Sookmyung Women’s University College of Pharmacy, Seoul 140-742, Republic of KoreaBisphenol A (BPA) and alkylphenols (APs) are well-known endocrine disrupting chemicals (EDCs) which may threat the next generations' health. We performed biomonitoring of these phenols in colostrums to assess risk of the phenols in breast-fed neonates. Study subjects were the lactating mothers who delivered babies within 2 weeks (N=325; 30.67 ± 3.45 years) and their neonates (N=326; embryonic period, 39.1 ± 1.5 weeks). BPA, nonylphenol (NP), and octylphenol (OP) in colostrums were quantified with LC/MS/MS. Information for environmental exposure sources of the phenols was obtained by questionnaires. As results, median level of BPA in colostrums was 7.8 ng/mL, while most NP or OP was not detected. Regarding health risks of phenols, levels of total NP in colostrums were elevated among sick mothers with toxemia, thyroid disorders, gastritis, and so forth than health mothers (3.51 ± 4.98 versus 2.04 ± 3.71 ng/mL, P=0.02). Dairy products intake and detergents use were positively correlated with total BPA levels (Ps<0.05). In conclusion, we estimate most neonates who are exposed to BPA rather than NP or OP via colostrums and recommend continuous biomonitoring of the phenols to clarify their suspected health risk on neonates and pregnant or gestation mothers.http://dx.doi.org/10.1155/2013/282381 |
| spellingShingle | B. Yi C. Kim M. Park Y. Han J. Y. Park M. Yang Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health International Journal of Endocrinology |
| title | Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health |
| title_full | Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health |
| title_fullStr | Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health |
| title_full_unstemmed | Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health |
| title_short | Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health |
| title_sort | association between endocrine disrupting phenols in colostrums and maternal and infant health |
| url | http://dx.doi.org/10.1155/2013/282381 |
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