PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer

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Main Authors: Abul Azad, Maryam Arshad, Daniele Generali, Katharina Feldinger, Merel Gijsen, Carla Strina, Mariarosa Cappelletti, Daniele Andreis, Russell Leek, Syed Haider, Pirkko‐Liisa Kellokumpu‐Lehtinen, Ioannis Roxanis, Adrian Llewellyn Harris, Abeer Mahmoud Shaaban, Heikki Joensuu, Anthony Kong
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Cancer Communications
Online Access:https://doi.org/10.1002/cac2.12632
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author Abul Azad
Maryam Arshad
Daniele Generali
Katharina Feldinger
Merel Gijsen
Carla Strina
Mariarosa Cappelletti
Daniele Andreis
Russell Leek
Syed Haider
Pirkko‐Liisa Kellokumpu‐Lehtinen
Ioannis Roxanis
Adrian Llewellyn Harris
Abeer Mahmoud Shaaban
Heikki Joensuu
Anthony Kong
author_facet Abul Azad
Maryam Arshad
Daniele Generali
Katharina Feldinger
Merel Gijsen
Carla Strina
Mariarosa Cappelletti
Daniele Andreis
Russell Leek
Syed Haider
Pirkko‐Liisa Kellokumpu‐Lehtinen
Ioannis Roxanis
Adrian Llewellyn Harris
Abeer Mahmoud Shaaban
Heikki Joensuu
Anthony Kong
author_sort Abul Azad
collection DOAJ
format Article
id doaj-art-ae3fd92c7a4645f2a36aa6dc4a9dc4e9
institution Kabale University
issn 2523-3548
language English
publishDate 2025-01-01
publisher Wiley
record_format Article
series Cancer Communications
spelling doaj-art-ae3fd92c7a4645f2a36aa6dc4a9dc4e92025-01-24T09:09:48ZengWileyCancer Communications2523-35482025-01-01451687310.1002/cac2.12632PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancerAbul Azad0Maryam Arshad1Daniele Generali2Katharina Feldinger3Merel Gijsen4Carla Strina5Mariarosa Cappelletti6Daniele Andreis7Russell Leek8Syed Haider9Pirkko‐Liisa Kellokumpu‐Lehtinen10Ioannis Roxanis11Adrian Llewellyn Harris12Abeer Mahmoud Shaaban13Heikki Joensuu14Anthony Kong15Department of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKInstitute of Genomic and Cancer Sciences Vincent Drive, University of Birmingham Birmingham UKU.O. Multidisciplinare di Patologia Mammaria U.S Terapia Molecolare e Farmacogenomica A.O. Instituti Ospitalieri di Cremona Viale Concordia 1 Cremona ItalyDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKU.O. Multidisciplinare di Patologia Mammaria U.S Terapia Molecolare e Farmacogenomica A.O. Instituti Ospitalieri di Cremona Viale Concordia 1 Cremona ItalyU.O. Multidisciplinare di Patologia Mammaria U.S Terapia Molecolare e Farmacogenomica A.O. Instituti Ospitalieri di Cremona Viale Concordia 1 Cremona ItalyU.O. Multidisciplinare di Patologia Mammaria U.S Terapia Molecolare e Farmacogenomica A.O. Instituti Ospitalieri di Cremona Viale Concordia 1 Cremona ItalyDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKDepartment of Oncology Tampere University Hospital and Tampere University Tampere FinlandThe Institute of Cancer Research London UKDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKDepartment of histopathology Queen Elizabeth Hospital Birmingham Birmingham UKDepartment of Oncology Helsinki University Hospital and University of Helsinki Helsinki FinlandDepartment of Oncology The Weatherall Institute of Molecular Medicine University of Oxford Oxford UKhttps://doi.org/10.1002/cac2.12632
spellingShingle Abul Azad
Maryam Arshad
Daniele Generali
Katharina Feldinger
Merel Gijsen
Carla Strina
Mariarosa Cappelletti
Daniele Andreis
Russell Leek
Syed Haider
Pirkko‐Liisa Kellokumpu‐Lehtinen
Ioannis Roxanis
Adrian Llewellyn Harris
Abeer Mahmoud Shaaban
Heikki Joensuu
Anthony Kong
PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
Cancer Communications
title PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
title_full PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
title_fullStr PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
title_full_unstemmed PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
title_short PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
title_sort ptpn9 regulates her3 phosphorylation during trastuzumab treatment and loss of ptpn9 is a potential biomarker for trastuzumab resistance in her2 positive breast cancer
url https://doi.org/10.1002/cac2.12632
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