Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance
Abstract The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07336-2 |
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| _version_ | 1832571258563198976 |
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| author | Liang Liu Xian Zhang Yan Chai Jianning Zhang Quanjun Deng Xin Chen |
| author_facet | Liang Liu Xian Zhang Yan Chai Jianning Zhang Quanjun Deng Xin Chen |
| author_sort | Liang Liu |
| collection | DOAJ |
| description | Abstract The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize skull bone marrow and SMCs by detailing the anatomical structures adjacent to the skull, the differences between skull and peripheral bone marrow, mainstream animal processing methods, and the role of skull bone marrow in monitoring various CNS diseases. Additionally, we highlight several unresolved issues based on current research findings, aiming to guide future research directions. |
| format | Article |
| id | doaj-art-ae3de7a122074f74affdad067f965cd7 |
| institution | Kabale University |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-ae3de7a122074f74affdad067f965cd72025-02-02T12:44:55ZengNature Publishing GroupCell Death and Disease2041-48892025-01-0116111710.1038/s41419-025-07336-2Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillanceLiang Liu0Xian Zhang1Yan Chai2Jianning Zhang3Quanjun Deng4Xin Chen5Department of Neurosurgery, Tianjin Medical University General HospitalDepartment of Neurosurgery, Tianjin Medical University General HospitalTianjin Neurological Institute, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous SystemDepartment of Neurosurgery, Tianjin Medical University General HospitalDepartment of Neurosurgery, Tianjin Medical University General HospitalDepartment of Neurosurgery, Tianjin Medical University General HospitalAbstract The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize skull bone marrow and SMCs by detailing the anatomical structures adjacent to the skull, the differences between skull and peripheral bone marrow, mainstream animal processing methods, and the role of skull bone marrow in monitoring various CNS diseases. Additionally, we highlight several unresolved issues based on current research findings, aiming to guide future research directions.https://doi.org/10.1038/s41419-025-07336-2 |
| spellingShingle | Liang Liu Xian Zhang Yan Chai Jianning Zhang Quanjun Deng Xin Chen Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance Cell Death and Disease |
| title | Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance |
| title_full | Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance |
| title_fullStr | Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance |
| title_full_unstemmed | Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance |
| title_short | Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance |
| title_sort | skull bone marrow and skull meninges channels redefining the landscape of central nervous system immune surveillance |
| url | https://doi.org/10.1038/s41419-025-07336-2 |
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